KRT5 and NADSYN1

Data Source:
BioGRID (affinity chromatography technology)

		KRT5	NADSYN1
Description		keratin 5	NAD synthetase 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Cytoplasm Cytosol
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding	NAD+ Synthase (glutamine-hydrolyzing) Activity Glutaminase Activity Protein Binding ATP Binding
	Biological Process	Cytoskeleton Organization Epidermis Development Keratinization Hemidesmosome Assembly Cornification	NAD Biosynthetic Process NAD Metabolic Process 'de Novo' NAD Biosynthetic Process
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	Nicotinate metabolism
Drugs		Zinc Zinc acetate	Glutamic acid
Diseases		Dowling-Degos disease Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Basal cell carcinoma ( 31174203 24403052 25855136 27539887) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)	Systemic lupus erythematosus ( 26502338) Vitamin D insufficiency ( 20541252) Vitamin D levels ( 29343764 20418485) Vitamin D levels (dietary vitamin D intake interaction) ( 29343764)
Interacting Genes		25 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL INCA1 KIFC3 KRT1 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT27 KRT28 KRT31 KRT35 KRT38 KRT40 PKP2 TCHP UBE3A	13 interacting genes: ANKS1A COL8A1 CREB5 CUTC FRS3 GPANK1 HGS HOXC8 MYO15B NOXA1 NTAQ1 TFG UPF1
Entrez ID		3852	55191
HPRD ID		01010	16309
Ensembl ID		ENSG00000186081	ENSG00000172890
Uniprot IDs		P13647	Q6IA69
PDB IDs		3TNU 6JFV	6OFB
Enriched GO Terms of Interacting Partners?
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