KRT5 and SAP18

Data Source:
BioGRID (proximity labelling technology)

		KRT5	SAP18
Description		keratin 5	Sin3A associated protein 18
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Histone Deacetylase Complex Nucleus Nucleoplasm Cytosol Nuclear Body Nuclear Speck Exon-exon Junction Complex ASAP Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Scaffold Protein Binding	Transcription Corepressor Activity RNA Binding Protein Binding Transcription Factor Binding
	Biological Process	Cytoskeleton Organization Epidermis Development Keratinization Hemidesmosome Assembly Cornification	Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II MRNA Processing RNA Splicing Positive Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	HDACs deacetylate histones NoRC negatively regulates rRNA expression Potential therapeutics for SARS
Drugs		Zinc Zinc acetate
Diseases		Dowling-Degos disease Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
GWAS		Basal cell carcinoma ( 31174203 24403052 25855136 27539887) Cutaneous squamous cell carcinoma ( 32041948) Keratinocyte cancer (MTAG) ( 31174203) Non-melanoma skin cancer ( 29739929) Squamous cell carcinoma ( 31174203)
Interacting Genes		25 interacting genes: ALOX12 ALOX12B APC DSP DST EVPL INCA1 KIFC3 KRT1 KRT14 KRT15 KRT16 KRT18 KRT19 KRT24 KRT25 KRT27 KRT28 KRT31 KRT35 KRT38 KRT40 PKP2 TCHP UBE3A	15 interacting genes: DEF6 ERBB3 HDAC1 IKZF1 INCA1 NOL12 NTAQ1 POLE2 RBM39 RNPS1 RPS3A SIN3A SUFU TADA3 TSC22D2
Entrez ID		3852	10284
HPRD ID		01010	04256
Ensembl ID		ENSG00000186081	ENSG00000150459
Uniprot IDs		P13647	O00422
PDB IDs		3TNU 6JFV	2HDE
Enriched GO Terms of Interacting Partners?
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