KPNA1 and POLR3C

Data Source:
BioGRID (two hybrid)

		KPNA1	POLR3C
Description		karyopherin subunit alpha 1	RNA polymerase III subunit C
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GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Dendrite Host Cell Glutamatergic Synapse	Nucleoplasm RNA Polymerase III Complex Cytosol
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Single-stranded DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding
	Biological Process	Regulation Of DNA Recombination Apoptotic DNA Fragmentation NLS-bearing Protein Import Into Nucleus Skeletal Muscle Satellite Cell Proliferation Satellite Cell Activation Involved In Skeletal Muscle Regeneration Modulation By Virus Of Host Cellular Process Regulation Of Apoptotic Process Regulation Of Canonical Wnt Signaling Pathway Intracellular Transport Of Virus Postsynapse To Nucleus Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus
Pathways		ISG15 antiviral mechanism Apoptosis induced DNA fragmentation Integration of provirus Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Vpr-mediated nuclear import of PICs Inhibition of nitric oxide production	Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
GWAS		Calcium levels ( 20705733) LDL cholesterol ( 30275531) LDL cholesterol levels ( 28334899) Mean corpuscular hemoglobin ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		45 interacting genes: ANP32A ANP32B ARNT BCAR3 CDKN1B CLK4 CRADD CSE1L ELAVL1 EPAS1 FOSL1 GOPC GTF2IRD1 H2BC21 H3-4 HDAC6 HIF1A IL1RAP KPNB1 LEF1 LINC01554 LMNB1 LMO4 MACROD1 MDM2 NMNAT1 NOSIP NUP50 NUP54 NUP62 ORC4 PAX5 PKM POLR3C RAG1 RANBP2 RUNX1T1 SENP2 SKP2 SRP19 STAT1 STAT3 TAF9 UBR5 USP1	39 interacting genes: ANKRD23 APP CAMK2B CEP44 CEP63 COIL DISC1 ENKD1 GOLGA2 GTF3C4 HAUS1 INCA1 KATNBL1 KIAA0408 KLHL2 KPNA1 KPNA3 KPNA5 KPNA6 KRT75 LZTS1 NCKIPSD PAX6 PICK1 PNMA5 POLR3G POLR3GL POU6F2 PRDM16 RBBP8NL ROCK1 ROPN1 SP100 TNR TRAF2 TRIM27 UBXN1 VAX1 VRTN
Entrez ID		3836	10623
HPRD ID		02819	17880
Ensembl ID		ENSG00000114030	ENSG00000186141
Uniprot IDs		B3KXZ2 P52294	Q9BUI4
PDB IDs		2JDQ 3TJ3 4B18 6WX9	2XUB 2XV4 5AFQ
Enriched GO Terms of Interacting Partners?
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