POLR3C and KPNA3

Data Source:
BioGRID (two hybrid)

		POLR3C	KPNA3
Description		RNA polymerase III subunit C	karyopherin subunit alpha 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm RNA Polymerase III Complex Cytosol	Nucleus Nuclear Pore Nucleoplasm Cytosol Host Cell
	Molecular Function	Single-stranded DNA Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding	Protein Binding Protein C-terminus Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus	NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Cellular Process Viral Entry Into Host Cell Protein-containing Complex Assembly Viral Penetration Into Host Nucleus
Pathways		Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases
GWAS			Inflammatory skin disease ( 25574825) Menopause (age at onset) ( 22267201) Obesity-related traits ( 23251661) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triiodothyronine/thyroxine ratio ( 30824882)
Interacting Genes		39 interacting genes: ANKRD23 APP CAMK2B CEP44 CEP63 COIL DISC1 ENKD1 GOLGA2 GTF3C4 HAUS1 INCA1 KATNBL1 KIAA0408 KLHL2 KPNA1 KPNA3 KPNA5 KPNA6 KRT75 LZTS1 NCKIPSD PAX6 PICK1 PNMA5 POLR3G POLR3GL POU6F2 PRDM16 RBBP8NL ROCK1 ROPN1 SP100 TNR TRAF2 TRIM27 UBXN1 VAX1 VRTN	54 interacting genes: ANKRD11 APOL6 ARNT BAHD1 BRD3 CCDC102B CDKN1B COIL CYHR1 DDX21 EPAS1 EPHA2 ERCC3 ESR2 FAM214B FAM50B FAM90A1 FTL GATA6 GRB10 GTF2H1 GTF2IRD1 HEXIM2 HIF1A HNRNPC HSPB1 KAT5 KPNB1 L3MBTL4 MAPK9 MAT2B MVP MYOD1 NFE2L2 NFKB1 NMNAT1 NUP50 POLR3C RAD52 RBBP4 RCC1 RPRD1A SLC5A11 TEX37 TGM2 TNIP3 TSSC4 UVSSA ZBTB24 ZCCHC10 ZCCHC12 ZNF131 ZNF76 ZNF764
Entrez ID		10623	3839
HPRD ID		17880	03536
Ensembl ID		ENSG00000186141	ENSG00000102753
Uniprot IDs		Q9BUI4	A0A024RDV7 O00505
PDB IDs		2XUB 2XV4 5AFQ
Enriched GO Terms of Interacting Partners?
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