KCNJ6 and COL4A5

Data Source:
BioGRID (two hybrid)

		KCNJ6	COL4A5
Description		potassium inwardly rectifying channel subfamily J member 6	collagen type IV alpha 5 chain
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Neuromuscular Junction Collagen-containing Extracellular Matrix
	Molecular Function	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Neuromuscular Junction Development Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway
Pathways		Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Regulation of expression of SLITs and ROBOs
Drugs		Ethanol Halothane Ifenprodil Isavuconazole
Diseases			Alport syndrome
GWAS		Body size at age 10 ( 32376654) Electroencephalographic traits in alcoholism ( 22554406) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Rosacea symptom severity ( 29771307)
Interacting Genes		63 interacting genes: ADRB2 AIG1 APOD BCL2L2 BET1 BIRC5 C14orf180 CMTM5 CNPY3 COL4A5 DLG1 DRD2 EDDM3B ERG28 FAM20B FIS1 FUNDC2 FXYD6 GABBR1 HMOX2 ICMT ITGAM KCNJ3 KCNJ9 LEPROTL1 LPAR3 LPCAT2 MIP MYO15B NINJ2 ORMDL2 PEX11G PEX16 PLLP PMP22 PNLIPRP1 RPRM RTP2 SCAMP4 SCARF1 SCD SERTM1 STATH STRIT1 SYT3 THSD7B TM6SF2 TMEM107 TMEM120B TMEM203 TMEM208 TMEM218 TMPPE TNFRSF10C TSPO2 UBIAD1 UNC50 UPK1B VSTM1 XIAP YIPF1 YIPF6 ZDHHC24	46 interacting genes: ABHD4 ANTXR2 ANXA7 APP ATP6V0B BSND CD53 CD79A CD93 CDKN1A CERS4 CLDN7 DAZAP2 DCN ELOVL4 ERGIC3 FAM209A FBLN2 FFAR2 FN1 GPX8 HABP2 KCNJ6 MATN2 MFF MMP9 MTIF3 NCR3LG1 NEMP1 NR1H2 OSM RELL2 RNF10 SAR1A SERPINE2 SLC10A4 SLC10A6 SLC16A2 SLC18A1 SLC35C2 SLC39A2 SMN1 THAP4 TK1 TMEM80 TSPO2
Entrez ID		3763	1287
HPRD ID		02929	02363
Ensembl ID		ENSG00000157542	ENSG00000188153
Uniprot IDs		P48051	A7MBN3 P29400 Q49AM6
PDB IDs			5NAZ
Enriched GO Terms of Interacting Partners?
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