COL4A5 and SERPINE2

Data Source:
HPRD (in vivo)

		COL4A5	SERPINE2
Description		collagen type IV alpha 5 chain	serpin family E member 2
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Neuromuscular Junction Collagen-containing Extracellular Matrix	Extracellular Region Extracellular Space Cytosol Platelet Alpha Granule Extrinsic Component Of External Side Of Plasma Membrane Neuromuscular Junction Collagen-containing Extracellular Matrix Extracellular Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength	Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Glycosaminoglycan Binding Heparin Binding
	Biological Process	Neuromuscular Junction Development Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway	Blood Coagulation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Plasminogen Activation Negative Regulation Of Sodium Ion Transport Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Processing Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Cerebellar Granular Layer Morphogenesis Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Cell Migration Secretion By Cell Secretory Granule Organization Negative Regulation Of Protein Catabolic Process Mating Plug Formation Negative Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Regulation Of Timing Of Cell Differentiation Positive Regulation Of Astrocyte Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Innervation Seminal Vesicle Epithelium Development Negative Regulation Of Platelet Aggregation
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization Regulation of expression of SLITs and ROBOs	Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Dissolution of Fibrin Clot
Drugs
Diseases		Alport syndrome
GWAS			Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil) ( 23648065) Blood protein levels ( 30072576 29875488) Cerebrospinal T-tau levels ( 28247064) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Height ( 20881960 31562340) Inflammatory biomarkers (multivariate analysis) ( 33110245) Mean platelet volume ( 32888494 27863252) Platelet-derived growth factor BB levels ( 27989323)
Interacting Genes		46 interacting genes: ABHD4 ANTXR2 ANXA7 APP ATP6V0B BSND CD53 CD79A CD93 CDKN1A CERS4 CLDN7 DAZAP2 DCN ELOVL4 ERGIC3 FAM209A FBLN2 FFAR2 FN1 GPX8 HABP2 KCNJ6 MATN2 MFF MMP9 MTIF3 NCR3LG1 NEMP1 NR1H2 OSM RELL2 RNF10 SAR1A SERPINE2 SLC10A4 SLC10A6 SLC16A2 SLC18A1 SLC35C2 SLC39A2 SMN1 THAP4 TK1 TMEM80 TSPO2	8 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 F2 FAM9B
Entrez ID		1287	5270
HPRD ID		02363	01510
Ensembl ID		ENSG00000188153	ENSG00000135919
Uniprot IDs		A7MBN3 P29400 Q49AM6	A0A024R451 A0A024R498 P07093
PDB IDs		5NAZ	4DY0 4DY7
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?