ITGA5 and ANGPTL3

Data Source:
HPRD (in vitro)

		ITGA5	ANGPTL3
Description		integrin subunit alpha 5	angiopoietin like 3
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GO Annotations	Cellular Component	Ruffle Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Cytoplasmic Vesicle Ruffle Membrane Integrin Alpha5-beta1 Complex Synapse Alphav-beta3 Integrin-vitronectin Complex	Extracellular Region Extracellular Space Early Endosome Golgi Apparatus Cell Surface Lamellipodium Collagen-containing Extracellular Matrix
	Molecular Function	Virus Receptor Activity Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding	Enzyme Inhibitor Activity Phospholipase Inhibitor Activity Signaling Receptor Binding Integrin Binding Growth Factor Activity Heparin Binding
	Biological Process	Angiogenesis Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Memory Positive Regulation Of Cell-substrate Adhesion CD40 Signaling Pathway Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Anoikis	Angiogenesis Glycerol Metabolic Process Fatty Acid Metabolic Process Phospholipid Metabolic Process Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Hormone Negative Regulation Of Phospholipase Activity Lipid Storage Positive Regulation Of Cell Migration Cholesterol Homeostasis Positive Regulation Of Angiogenesis Artery Morphogenesis Positive Regulation Of Lipid Catabolic Process Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis Acylglycerol Homeostasis Phospholipid Homeostasis Triglyceride Homeostasis
Pathways		Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration	Assembly of active LPL and LIPC lipase complexes NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
Drugs		Resveratrol
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood metabolite levels ( 24816252) Blood protein levels ( 30072576) Cholesterol, total ( 24097068 25961943 20686565 26582766) Crohn's disease ( 28067908) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219 19936222) Metabolite levels ( 22916037) Metabolite levels (lipid measures) ( 27005778) Regular attendance at a gym or sports club ( 29970889) Total cholesterol levels ( 28334899) Total triglycerides levels ( 26690388) Triglyceride levels ( 28334899 29615537) Triglycerides ( 24097068 18193043 18193044 20864672 19060906 20139978 25961943 20686565 26582766)
Interacting Genes		31 interacting genes: ANGPT1 ANGPT2 ANGPTL3 ARHGAP5 AUP1 CD9 CLK1 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GPR182 GRK6 ITGB1 ITGB3 ITGB5 L1CAM LGALS3BP NISCH PECAM1 RABIF SHARPIN SPP1 STAMBP TNC UBAP1 VCL	4 interacting genes: ITGA5 ITGAV ITGB3 UBC
Entrez ID		3678	27329
HPRD ID		00627	10381
Ensembl ID		ENSG00000161638	ENSG00000132855
Uniprot IDs		B2R627 P08648	Q9Y5C1
PDB IDs		3VI3 3VI4 4WJK 4WK0 4WK2 4WK4	6EUA
Enriched GO Terms of Interacting Partners?
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