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ITGA5 and PECAM1
Data Source:
HPRD
(in vivo)
ITGA5
PECAM1
Description
integrin subunit alpha 5
platelet and endothelial cell adhesion molecule 1
Image
GO Annotations
Cellular Component
Ruffle
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Cytoplasmic Vesicle
Ruffle Membrane
Integrin Alpha5-beta1 Complex
Synapse
Alphav-beta3 Integrin-vitronectin Complex
Extracellular Space
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Secretory Granule Membrane
Platelet Alpha Granule Membrane
Protein-containing Complex
Membrane Raft
Extracellular Exosome
Molecular Function
Virus Receptor Activity
Epidermal Growth Factor Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
Vascular Endothelial Growth Factor Receptor 2 Binding
Metal Ion Binding
Transmembrane Signaling Receptor Activity
Protein Binding
Protein Homodimerization Activity
Biological Process
Angiogenesis
Cell-substrate Junction Assembly
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Integrin-mediated Signaling Pathway
Female Pregnancy
Memory
Positive Regulation Of Cell-substrate Adhesion
CD40 Signaling Pathway
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Wound Healing, Spreading Of Epidermal Cells
Endodermal Cell Differentiation
Viral Entry Into Host Cell
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Positive Regulation Of Sprouting Angiogenesis
Negative Regulation Of Anoikis
Positive Regulation Of Protein Phosphorylation
Platelet Degranulation
Phagocytosis
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Leukocyte Cell-cell Adhesion
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Recognition
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Maintenance Of Blood-brain Barrier
Monocyte Extravasation
Neutrophil Degranulation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Diapedesis
Establishment Of Endothelial Barrier
Bicellular Tight Junction Assembly
Glomerular Endothelium Development
Neutrophil Extravasation
Cell-cell Adhesion
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Positive Regulation Of Protein Localization To Cell-cell Junction
Pathways
Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Signal transduction by L1
RUNX2 regulates genes involved in cell migration
Platelet degranulation
Cell surface interactions at the vascular wall
PECAM1 interactions
Integrin cell surface interactions
Platelet sensitization by LDL
Neutrophil degranulation
Drugs
Resveratrol
Diseases
GWAS
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Coronary artery disease (
32469254
29212778
33020668
)
Pulse pressure (
27841878
30578418
)
Systolic blood pressure (
27841878
)
Interacting Genes
31 interacting genes:
ANGPT1
ANGPT2
ANGPTL3
ARHGAP5
AUP1
CD9
CLK1
COL18A1
COL1A1
EGFR
ERBB2
FGFR2
FLT4
FN1
GIPC1
GPR182
GRK6
ITGB1
ITGB3
ITGB5
L1CAM
LGALS3BP
NISCH
PECAM1
RABIF
SHARPIN
SPP1
STAMBP
TNC
UBAP1
VCL
22 interacting genes:
CD38
CSK
CTNNB1
DSP
EFNB2
FYN
HCK
INPP5D
ITGA5
ITGB3
JUP
LCK
LYN
PIK3R1
PLCG1
PRKCE
PRPF40A
PTPN11
PTPN6
SRC
XRCC6
YES1
Entrez ID
3678
5175
HPRD ID
00627
01425
Ensembl ID
ENSG00000161638
ENSG00000261371
Uniprot IDs
B2R627
P08648
P16284
PDB IDs
3VI3
3VI4
4WJK
4WK0
4WK2
4WK4
2KY5
5C14
5GNI
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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