ITGA5 and UBAP1

Data Source:
BioGRID (pull down)

		ITGA5	UBAP1
Description		integrin subunit alpha 5	ubiquitin associated protein 1
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GO Annotations	Cellular Component	Ruffle Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell-cell Junction Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Cytoplasmic Vesicle Ruffle Membrane Integrin Alpha5-beta1 Complex Synapse Alphav-beta3 Integrin-vitronectin Complex	ESCRT I Complex Cytoplasm Cytosol Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle Host Cell
	Molecular Function	Virus Receptor Activity Epidermal Growth Factor Receptor Binding Platelet-derived Growth Factor Receptor Binding Integrin Binding Protein Binding Vascular Endothelial Growth Factor Receptor 2 Binding Metal Ion Binding	Protein Binding Ubiquitin Binding
	Biological Process	Angiogenesis Cell-substrate Junction Assembly Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Female Pregnancy Memory Positive Regulation Of Cell-substrate Adhesion CD40 Signaling Pathway Extracellular Matrix Organization Positive Regulation Of Cell Migration Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-substrate Adhesion Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Viral Entry Into Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Anoikis	Protein Transport Endosomal Transport Viral Life Cycle Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Intracellular Transport Of Virus
Pathways		Elastic fibre formation Fibronectin matrix formation Cell surface interactions at the vascular wall Integrin cell surface interactions Integrin cell surface interactions Signal transduction by L1 RUNX2 regulates genes involved in cell migration	Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy
Drugs		Resveratrol
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Creatine kinase levels ( 29403010) Fruit consumption ( 32066663) Pulse pressure ( 30224653)
Interacting Genes		31 interacting genes: ANGPT1 ANGPT2 ANGPTL3 ARHGAP5 AUP1 CD9 CLK1 COL18A1 COL1A1 EGFR ERBB2 FGFR2 FLT4 FN1 GIPC1 GPR182 GRK6 ITGB1 ITGB3 ITGB5 L1CAM LGALS3BP NISCH PECAM1 RABIF SHARPIN SPP1 STAMBP TNC UBAP1 VCL	5 interacting genes: ITGA5 MAP3K1 PPIC PTPN23 UBC
Entrez ID		3678	51271
HPRD ID		00627	15597
Ensembl ID		ENSG00000161638	ENSG00000165006
Uniprot IDs		B2R627 P08648	A0A6G6AA68 Q9NZ09
PDB IDs		3VI3 3VI4 4WJK 4WK0 4WK2 4WK4	1WGN 4AE4 5LM1
Enriched GO Terms of Interacting Partners?
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