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ANGPTL3 and ITGA5
Data Source:
HPRD
(in vitro)
ANGPTL3
ITGA5
Description
angiopoietin like 3
integrin subunit alpha 5
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Early Endosome
Golgi Apparatus
Cell Surface
Lamellipodium
Collagen-containing Extracellular Matrix
Ruffle
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Cytoplasmic Vesicle
Ruffle Membrane
Integrin Alpha5-beta1 Complex
Synapse
Alphav-beta3 Integrin-vitronectin Complex
Molecular Function
Enzyme Inhibitor Activity
Phospholipase Inhibitor Activity
Signaling Receptor Binding
Integrin Binding
Growth Factor Activity
Heparin Binding
Virus Receptor Activity
Epidermal Growth Factor Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Integrin Binding
Protein Binding
Vascular Endothelial Growth Factor Receptor 2 Binding
Metal Ion Binding
Biological Process
Angiogenesis
Glycerol Metabolic Process
Fatty Acid Metabolic Process
Phospholipid Metabolic Process
Cell-matrix Adhesion
Signal Transduction
Integrin-mediated Signaling Pathway
Cholesterol Metabolic Process
Phospholipid Catabolic Process
Response To Hormone
Negative Regulation Of Phospholipase Activity
Lipid Storage
Positive Regulation Of Cell Migration
Cholesterol Homeostasis
Positive Regulation Of Angiogenesis
Artery Morphogenesis
Positive Regulation Of Lipid Catabolic Process
Regulation Of Lipoprotein Lipase Activity
Negative Regulation Of Lipoprotein Lipase Activity
Lipid Homeostasis
Acylglycerol Homeostasis
Phospholipid Homeostasis
Triglyceride Homeostasis
Angiogenesis
Cell-substrate Junction Assembly
Cell Adhesion
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Leukocyte Cell-cell Adhesion
Integrin-mediated Signaling Pathway
Female Pregnancy
Memory
Positive Regulation Of Cell-substrate Adhesion
CD40 Signaling Pathway
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cell-substrate Adhesion
Cell Adhesion Mediated By Integrin
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Wound Healing, Spreading Of Epidermal Cells
Endodermal Cell Differentiation
Viral Entry Into Host Cell
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Leukocyte Migration
Positive Regulation Of Sprouting Angiogenesis
Negative Regulation Of Anoikis
Pathways
Assembly of active LPL and LIPC lipase complexes
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
Elastic fibre formation
Fibronectin matrix formation
Cell surface interactions at the vascular wall
Integrin cell surface interactions
Integrin cell surface interactions
Signal transduction by L1
RUNX2 regulates genes involved in cell migration
Drugs
Resveratrol
Diseases
GWAS
Blood metabolite levels (
24816252
)
Blood protein levels (
30072576
)
Cholesterol, total (
24097068
25961943
20686565
26582766
)
Crohn's disease (
28067908
)
LDL cholesterol (
24097068
25961943
20686565
)
LDL cholesterol levels (
28334899
)
Lipid metabolism phenotypes (
22286219
19936222
)
Metabolite levels (
22916037
)
Metabolite levels (lipid measures) (
27005778
)
Regular attendance at a gym or sports club (
29970889
)
Total cholesterol levels (
28334899
)
Total triglycerides levels (
26690388
)
Triglyceride levels (
28334899
29615537
)
Triglycerides (
24097068
18193043
18193044
20864672
19060906
20139978
25961943
20686565
26582766
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
4 interacting genes:
ITGA5
ITGAV
ITGB3
UBC
31 interacting genes:
ANGPT1
ANGPT2
ANGPTL3
ARHGAP5
AUP1
CD9
CLK1
COL18A1
COL1A1
EGFR
ERBB2
FGFR2
FLT4
FN1
GIPC1
GPR182
GRK6
ITGB1
ITGB3
ITGB5
L1CAM
LGALS3BP
NISCH
PECAM1
RABIF
SHARPIN
SPP1
STAMBP
TNC
UBAP1
VCL
Entrez ID
27329
3678
HPRD ID
10381
00627
Ensembl ID
ENSG00000132855
ENSG00000161638
Uniprot IDs
Q9Y5C1
B2R627
P08648
PDB IDs
6EUA
3VI3
3VI4
4WJK
4WK0
4WK2
4WK4
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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