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IFNGR2 and TMEM60
Data Source:
BioGRID
(two hybrid)
IFNGR2
TMEM60
Description
interferon gamma receptor 2
transmembrane protein 60
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Integral Component Of Membrane
Cytoplasmic Vesicle Membrane
Integral Component Of Membrane
Molecular Function
Cytokine Receptor Activity
Interferon-gamma Receptor Activity
Protein Binding
Protein Binding
Biological Process
Cell Surface Receptor Signaling Pathway
Response To Virus
Cytokine-mediated Signaling Pathway
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways
Interferon gamma signaling
Regulation of IFNG signaling
Regulation of IFNG signaling
Potential therapeutics for SARS
Drugs
Interferon gamma-1b
Diseases
Tuberculosis
IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
22936669
23128233
)
Diverticular disease (
30177863
)
Educational attainment (
25201988
)
Inflammatory bowel disease (
28067908
)
Multiple sclerosis (
31604244
24076602
)
Obesity-related traits (
23251661
)
Psoriasis (
25854761
)
Rheumatoid arthritis (
30423114
24390342
)
Chronic kidney disease (
20383146
)
Estimated glomerular filtration rate (
31152163
31451708
30604766
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Interacting Genes
42 interacting genes:
ADIPOQ
ANXA5
BNIP3
BRICD5
BTNL8
CAMK2D
CD302
CLDN19
CLEC7A
CXCL9
DNAJA3
EMP3
ENTPD3
ERMP1
GIMAP5
IFNG
IFNGR1
INSIG2
JAGN1
JAK2
NR3C1
PMP22
RPL37A
RTP2
SEC22B
SFT2D2
SFTPC
SLC52A1
SMIM3
STRIT1
TMEM120B
TMEM140
TMEM199
TMEM218
TMEM254
TMEM60
TMEM97
TRARG1
TREX1
TSPAN2
UNC50
ZDHHC24
89 interacting genes:
AMIGO1
ANKS6
APOL2
AQP2
AQP6
ASGR2
BEST2
BIK
BSND
CD300A
CD53
CD74
CLDN7
CNR2
CPLX4
CYB5R3
EBP
EDA
ERGIC3
EVI2B
FAM209A
FFAR2
FNDC9
GJA8
GJB5
GJB6
GORAB
GPR152
GPR42
GPX8
HERPUD2
HIBADH
HSD17B13
IFNGR2
KCNK5
KIAA2013
LEUTX
LHFPL5
LMNA
LRRC3B
LRRC59
MFF
MGST3
MMD
MMGT1
PAGE1
PGRMC2
PI16
REEP2
REEP4
RETREG3
RHCG
RNASEK
SCN3B
SLC10A1
SLC10A6
SLC13A4
SLC16A2
SLC18A1
SLC23A2
SLC30A2
SLC30A4
SLC35E3
SLC38A1
SLC39A2
SLC4A1
SLC7A8
SPAG4
SPNS3
SSMEM1
STOM
STX1A
SYT1
THAP4
TLCD4
TMCO5A
TMED9
TMEM139
TMEM14B
TMEM203
TMEM237
TMEM45B
TMEM52B
TMEM86B
TMEM9
TMPPE
TMPRSS2
TTYH1
VMA21
Entrez ID
3460
85025
HPRD ID
00956
12923
Ensembl ID
ENSG00000159128
ENSG00000135211
Uniprot IDs
A8K881
E7EUY1
P38484
Q9H2L4
PDB IDs
5EH1
6E3K
6E3L
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Difference)
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Tagcloud (Intersection)
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