TMEM60 and GJB6

Data Source:
BioGRID (two hybrid)

		TMEM60	GJB6
Description		transmembrane protein 60	gap junction protein beta 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Cytosol Actin Filament Gap Junction Connexin Complex Integral Component Of Membrane Apical Plasma Membrane Cell Junction
	Molecular Function	Protein Binding	Gap Junction Channel Activity Protein Binding Microtubule Binding Beta-tubulin Binding Actin Filament Binding Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling
	Biological Process		Apoptotic Process Cell-cell Signaling Aging Sensory Perception Of Sound Negative Regulation Of Cell Population Proliferation Cell Communication By Electrical Coupling Gap Junction Assembly Response To Lipopolysaccharide Maintenance Of Blood-brain Barrier Ear Morphogenesis Inner Ear Development Response To Electrical Stimulus Transmembrane Transport Cellular Response To Glucose Stimulus Gap Junction-mediated Intercellular Transport
Pathways			Gap junction assembly
Drugs
Diseases			Ectodermal dysplasia, hidrotic; Clouston syndrome Deafness, autosomal recessive
GWAS		Chronic kidney disease ( 20383146) Estimated glomerular filtration rate ( 31152163 31451708 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199)	Facial emotion recognition (happy faces) ( 28608620)
Interacting Genes		89 interacting genes: AMIGO1 ANKS6 APOL2 AQP2 AQP6 ASGR2 BEST2 BIK BSND CD300A CD53 CD74 CLDN7 CNR2 CPLX4 CYB5R3 EBP EDA ERGIC3 EVI2B FAM209A FFAR2 FNDC9 GJA8 GJB5 GJB6 GORAB GPR152 GPR42 GPX8 HERPUD2 HIBADH HSD17B13 IFNGR2 KCNK5 KIAA2013 LEUTX LHFPL5 LMNA LRRC3B LRRC59 MFF MGST3 MMD MMGT1 PAGE1 PGRMC2 PI16 REEP2 REEP4 RETREG3 RHCG RNASEK SCN3B SLC10A1 SLC10A6 SLC13A4 SLC16A2 SLC18A1 SLC23A2 SLC30A2 SLC30A4 SLC35E3 SLC38A1 SLC39A2 SLC4A1 SLC7A8 SPAG4 SPNS3 SSMEM1 STOM STX1A SYT1 THAP4 TLCD4 TMCO5A TMED9 TMEM139 TMEM14B TMEM203 TMEM237 TMEM45B TMEM52B TMEM86B TMEM9 TMPPE TMPRSS2 TTYH1 VMA21	14 interacting genes: CHRM5 CNST EBP F2RL1 GJB2 GPR61 KLRC1 LHFPL5 MS4A13 SEC22A SEC22B SLC10A6 TMEM218 TMEM60
Entrez ID		85025	10804
HPRD ID		12923	05107
Ensembl ID		ENSG00000135211	ENSG00000121742
Uniprot IDs		Q9H2L4	A0A024RDS4 O95452
PDB IDs
Enriched GO Terms of Interacting Partners?
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