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IFNGR2 and NR3C1
Data Source:
HPRD
(in vitro)
IFNGR2
NR3C1
Description
interferon gamma receptor 2
nuclear receptor subfamily 3 group C member 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Integral Component Of Membrane
Cytoplasmic Vesicle Membrane
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Matrix
Microtubule Organizing Center
Spindle
Cytosol
Nuclear Speck
Protein-containing Complex
Molecular Function
Cytokine Receptor Activity
Interferon-gamma Receptor Activity
Protein Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
RNA Binding
Nuclear Receptor Activity
Glucocorticoid Receptor Activity
Steroid Binding
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Hsp90 Protein Binding
Steroid Hormone Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Cell Surface Receptor Signaling Pathway
Response To Virus
Cytokine-mediated Signaling Pathway
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Apoptotic Process
Cell Cycle
Chromosome Segregation
Signal Transduction
Intracellular Steroid Hormone Receptor Signaling Pathway
Glucocorticoid Receptor Signaling Pathway
Glucocorticoid Mediated Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Cell Division
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Glucocorticoid Stimulus
Cellular Response To Dexamethasone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways
Interferon gamma signaling
Regulation of IFNG signaling
Regulation of IFNG signaling
Potential therapeutics for SARS
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Circadian Clock
SUMOylation of intracellular receptors
PTK6 Expression
Regulation of RUNX2 expression and activity
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Potential therapeutics for SARS
Drugs
Interferon gamma-1b
Flunisolide
Diflorasone
Alclometasone
Medrysone
Amcinonide
Fluorometholone
Megestrol acetate
Levonorgestrel
Beclomethasone dipropionate
Progesterone
Spironolactone
Betamethasone
Desoximetasone
Fluticasone propionate
Fluocinolone acetonide
Ulobetasol
Triamcinolone
Prednisone
Flumethasone
Fludrocortisone
Norethisterone
Hydrocortisone
Mometasone
Hydrocortamate
Mifepristone
Clocortolone
Flurandrenolide
Prednisolone
Loteprednol etabonate
Rimexolone
Methylprednisolone
Clobetasol propionate
Fluocinonide
Prednicarbate
Fluoxymesterone
Budesonide
Dexamethasone
Desonide
Cortisone acetate
Paramethasone
Drospirenone
Ciclesonide
Hexane-1,6-Diol
Aldosterone
ORG-34517
Difluprednate
Ulipristal
Fluticasone furoate
Tixocortol
Difluocortolone
Gestrinone
Deflazacort
Onapristone
Cortivazol
Clobetasone
Fluticasone
Mometasone furoate
Hydrocortisone aceponate
Hydrocortisone acetate
Hydrocortisone butyrate
Hydrocortisone cypionate
Hydrocortisone phosphate
Hydrocortisone probutate
Hydrocortisone valerate
Segesterone acetate
Prednisolone phosphate
Dexamethasone acetate
Betamethasone phosphate
Prednisolone acetate
Diseases
Tuberculosis
IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
28067908
22936669
23128233
)
Diverticular disease (
30177863
)
Educational attainment (
25201988
)
Inflammatory bowel disease (
28067908
)
Multiple sclerosis (
31604244
24076602
)
Obesity-related traits (
23251661
)
Psoriasis (
25854761
)
Rheumatoid arthritis (
30423114
24390342
)
Atrial fibrillation (
30061737
29892015
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Night sleep phenotypes (
27126917
)
PR interval (
32439900
)
Spatial processing (
31596458
)
Interacting Genes
42 interacting genes:
ADIPOQ
ANXA5
BNIP3
BRICD5
BTNL8
CAMK2D
CD302
CLDN19
CLEC7A
CXCL9
DNAJA3
EMP3
ENTPD3
ERMP1
GIMAP5
IFNG
IFNGR1
INSIG2
JAGN1
JAK2
NR3C1
PMP22
RPL37A
RTP2
SEC22B
SFT2D2
SFTPC
SLC52A1
SMIM3
STRIT1
TMEM120B
TMEM140
TMEM199
TMEM218
TMEM254
TMEM60
TMEM97
TRARG1
TREX1
TSPAN2
UNC50
ZDHHC24
160 interacting genes:
ABCC1
ADA
AR
ARPC5
BAG1
C1orf94
CALM1
CALR
CEBPA
CEBPB
CENPB
CHD9
COPS6
CREB1
CREBBP
DAP3
DAPK1
DCAF6
DDX54
DNMT3L
DOCK3
DTD1
ECD
EFHC2
EGFR
EPB41L1
ETS1
ETS2
FAM161B
FKBP4
FTH1
FYN
GNB1
GNB2
GRIP1
H3C1
HDAC1
HDAC6
HMGB1
HMGB2
HMOX2
HNRNPA1
HNRNPU
HSP90AA1
HSP90AB1
HSPA1A
HSPD1
IDE
IFNGR2
JUN
KAT5
KDM5A
KPNA2
KRTCAP3
LCK
LPXN
LRIF1
MAFF
MAPK1
MAPK15
MAPK8
MDM2
MED1
MED14
MED25
MSX2
NCL
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NEDD4L
NFKB1
NFKB2
NR0B1
NR0B2
NR1H3
NR2E3
NR2F2
NR2F6
NR3C2
NR4A1
NRIP1
NUP54
ONECUT1
OSGEP
PBX1
PELP1
PIAS2
PML
POLR1D
POU1F1
POU2F1
POU2F2
PPARGC1A
PRDX3
PRKACA
PRKDC
PRPF6
PSMC3IP
PTGES3
PTMS
RACK1
RAD54L2
RAD9A
RAF1
RAN
RARA
RBM14
RELA
RFPL2
RNF14
RXRB
SFN
SGTA
SHKBP1
SLC25A4
SMAD3
SMARCA2
SMARCA4
SMARCB1
SMARCC1
SMARCD1
SMARCE1
SPIN2A
SRA1
SRC
STAT3
STAT5A
STAT5B
STRN3
STUB1
SUMO1
SUMO4
SVIL
SYT1
TADA2A
TBP
TDG
TGFB1I1
TMF1
TNS4
TP53
TRIM24
TRIM28
TSG101
TXN
UBB
UBE2I
UBE2L3
WTIP
YWHAH
ZBTB16
ZBTB20
ZBTB3
ZBTB9
ZNF496
Entrez ID
3460
2908
HPRD ID
00956
00679
Ensembl ID
ENSG00000159128
ENSG00000113580
Uniprot IDs
A8K881
E7EUY1
P38484
B7Z7I2
E5KQF5
E5KQF6
F1D8N4
P04150
PDB IDs
5EH1
6E3K
6E3L
1M2Z
1NHZ
1P93
3BQD
3CLD
3E7C
3H52
3K22
3K23
4CSJ
4HN5
4HN6
4LSJ
4MDD
4P6W
4P6X
4UDC
4UDD
5CBX
5CBY
5CBZ
5CC1
5E69
5E6A
5E6B
5E6C
5E6D
5EMC
5EMP
5EMQ
5G3J
5G5W
5NFP
5NFT
5UC3
5VA0
5VA7
6BQU
6CFN
6DXK
6EL6
6EL7
6EL9
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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