ICAM3 and CLDN19

Data Source:
BioGRID (two hybrid)

		ICAM3	CLDN19
Description		intercellular adhesion molecule 3	claudin 19
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Exosome	Nucleus Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Basolateral Plasma Membrane Apical Junction Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Signaling Receptor Binding Integrin Binding Protein Binding	Structural Molecule Activity Identical Protein Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Phagocytosis Cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response Cell-cell Adhesion	Positive Regulation Of Protein Phosphorylation Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Neuronal Action Potential Propagation Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Response To Stimulus Negative Regulation Of Wound Healing Bicellular Tight Junction Assembly Regulation Of Transepithelial Transport Positive Regulation Of Cell Junction Assembly
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions CD209 (DC-SIGN) signaling	Tight junction interactions
Drugs
Diseases
GWAS		Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)
Interacting Genes		20 interacting genes: APP BRICD5 CD209 CLDN19 CLDN4 CLEC4M EDDM3B EZR ITGAD ITGAL ITGB2 MSN NINJ2 PRKCQ SEC22A SFTPC SMCO4 SMIM1 TSPO ZBTB16	63 interacting genes: AQP6 AQP9 BCL2L13 BIK BSCL2 BTN2A1 CD200R1 CD53 CD74 CLEC14A CLEC2D CLRN1 CREB3 CXCR3 CYSRT1 ERGIC3 FAM209A FCGR1A FCGRT FKBP7 FNDC9 GGT7 GJA8 GORAB GPR161 GPX8 HSD17B13 ICAM3 IFNGR2 IL3RA KEL KIR2DL3 KRT31 KRT34 LAPTM5 LRRC25 LRRC4C MFF MS4A14 MS4A4A MUC1 PDZK1IP1 PKD2L1 PLEKHB2 PVR SAR1A SCARB2 SGPL1 SLAMF6 SLC10A1 SLC35C2 SPACA1 SRPK2 STOM STOML3 SUSD3 SYNE4 TM4SF18 TMEM106C TMEM248 TMEM52B TMEM80 TNFSF14
Entrez ID		3385	149461
HPRD ID		00889	10834
Ensembl ID		ENSG00000076662	ENSG00000164007
Uniprot IDs		A0A024R7C1 K7ERN2 P32942	Q8N6F1
PDB IDs		1T0P
Enriched GO Terms of Interacting Partners?
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