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HTR2C and CBX3
Data Source:
BioGRID
(two hybrid)
HTR2C
CBX3
Description
5-hydroxytryptamine receptor 2C
chromobox 3
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Dendrite
Synapse
G Protein-coupled Serotonin Receptor Complex
Chromosome, Centromeric Region
Condensed Chromosome, Centromeric Region
Chromosome, Telomeric Region
Chromatin
Euchromatin
Heterochromatin
Nucleus
Nuclear Envelope
Nuclear Inner Membrane
Nucleoplasm
Pericentric Heterochromatin
Spindle
Senescence-associated Heterochromatin Focus
RNA Polymerase II Transcription Regulator Complex
Site Of DNA Damage
Molecular Function
Gq/11-coupled Serotonin Receptor Activity
G Protein-coupled Serotonin Receptor Activity
Protein Binding
Neurotransmitter Receptor Activity
Identical Protein Binding
Serotonin Binding
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
Protein Binding
Transcription Factor Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Histone Methyltransferase Binding
Biological Process
Behavioral Fear Response
Cellular Calcium Ion Homeostasis
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating Serotonin Receptor Signaling Pathway
Chemical Synaptic Transmission
Locomotory Behavior
Feeding Behavior
Positive Regulation Of Phosphatidylinositol Biosynthetic Process
CGMP-mediated Signaling
Regulation Of Nervous System Process
Regulation Of Appetite
Response To Drug
Regulation Of Corticotropin-releasing Hormone Secretion
Positive Regulation Of Fat Cell Differentiation
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
G Protein-coupled Serotonin Receptor Signaling Pathway
Chromatin Remodeling
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Transcription, DNA-templated
Rhythmic Process
Negative Regulation Of G0 To G1 Transition
Cellular Response To Dexamethasone Stimulus
Pathways
Serotonin receptors
G alpha (q) signalling events
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
RNA Polymerase I Promoter Escape
Transcriptional Regulation by E2F6
Drugs
Tramadol
Ziprasidone
Methysergide
Cabergoline
Amitriptyline
Olanzapine
Clozapine
Mirtazapine
Loxapine
Promazine
Cyproheptadine
Imipramine
Fluoxetine
Chlorpromazine
Chlorpromazine
Haloperidol
Nortriptyline
Amoxapine
Fenfluramine
Lisuride
Fluphenazine
Trazodone
Ergotamine
Apomorphine
Paroxetine
Trimipramine
Risperidone
Propiomazine
Minaprine
Cyclobenzaprine
Maprotiline
Ergoloid mesylate
Tegaserod
Doxepin
Nefazodone
Desipramine
Escitalopram
Pergolide
Dexfenfluramine
Bromocriptine
Ketamine
Quetiapine
Aripiprazole
Chlorprothixene
Clomipramine
Paliperidone
Yohimbine
Methotrimeprazine
Midomafetamine
4-Bromo-2,5-dimethoxyphenethylamine
Lorcaserin
Dapoxetine
Lofexidine
Epicept NP-1
Sertindole
Mianserin
Pizotifen
Asenapine
Ocaperidone
Dotarizine
Deramciclane
Agomelatine
Esmirtazapine
Captodiame
Etoperidone
Lorpiprazole
Setiptiline
Dihydroergocornine
m-Chlorophenylpiperazine
Gilteritinib
Sarpogrelate
Eplivanserin
Tiapride
Dihydroergocristine
2,5-Dimethoxy-4-ethylthioamphetamine
Aripiprazole lauroxil
Diseases
GWAS
Metabolite levels (
23823483
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
34 interacting genes:
APBA1
ARRB2
ATP2B3
ATP6AP2
ATP6V0C
C4orf3
CALM1
CBX3
CNIH1
CRELD1
DLG4
EMP1
ERG28
GHITM
GJA1
GNAQ
GPR37
GPRC5B
LIN7C
MFSD14A
MPDZ
PLP1
RTN4
SGCB
SLC29A1
SLC39A1
SLC39A9
SNTA1
SPNS1
TM9SF2
TMBIM6
TMEM147
TMEM94
TPI1
46 interacting genes:
ADAMTSL4
ADNP2
ARL5A
ATXN7L2
AURKA
AURKB
BARD1
CACNB4
CBX1
CBX5
CDC42
DNMT3B
DSN1
GDF15
H1-4
H3-4
H3C1
H4C1
HECW2
HIPK2
HTR2C
KLF11
L3MBTL1
LAP3
LBR
LRIF1
MGA
MIS12
MKI67
MRPL12
NSD3
NSL1
PIM1
PRR14
RAD54L2
SP100
STK16
SUV39H1
TAF4
TRIM24
TRIM28
VHL
ZNF10
ZNF280C
ZNF280D
ZNF496
Entrez ID
3358
11335
HPRD ID
02429
05130
Ensembl ID
ENSG00000147246
ENSG00000122565
Uniprot IDs
K9J958
P28335
A4D177
Q13185
PDB IDs
6BQG
6BQH
2L11
3DM1
3KUP
3TZD
5T1I
6HW2
Enriched GO Terms of Interacting Partners
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