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CBX3 and SUV39H1
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, two hybrid)
CBX3
SUV39H1
Description
chromobox 3
suppressor of variegation 3-9 homolog 1
Image
GO Annotations
Cellular Component
Chromosome, Centromeric Region
Condensed Chromosome, Centromeric Region
Chromosome, Telomeric Region
Chromatin
Euchromatin
Heterochromatin
Nucleus
Nuclear Envelope
Nuclear Inner Membrane
Nucleoplasm
Pericentric Heterochromatin
Spindle
Senescence-associated Heterochromatin Focus
RNA Polymerase II Transcription Regulator Complex
Site Of DNA Damage
Chromosome, Centromeric Region
Heterochromatin
Condensed Nuclear Chromosome
Nucleus
Nuclear Lamina
Nucleoplasm
Chromatin Silencing Complex
RDNA Heterochromatin
Molecular Function
Protein Binding
Transcription Factor Binding
Enzyme Binding
Protein Domain Specific Binding
Identical Protein Binding
Histone Methyltransferase Binding
Transcription Regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Protein Binding
Zinc Ion Binding
S-adenosylmethionine-dependent Methyltransferase Activity
Histone-lysine N-methyltransferase Activity
Histone Methyltransferase Activity
Histone Methyltransferase Activity (H3-K9 Specific)
Protein N-terminus Binding
Biological Process
Chromatin Remodeling
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Transcription, DNA-templated
Rhythmic Process
Negative Regulation Of G0 To G1 Transition
Cellular Response To Dexamethasone Stimulus
Negative Regulation Of Transcription By RNA Polymerase II
RDNA Heterochromatin Assembly
Chromatin Organization
RRNA Processing
Cellular Response To DNA Damage Stimulus
Cell Cycle
Viral Process
Cell Differentiation
Histone Lysine Methylation
Histone H3-K9 Dimethylation
Histone H3-K9 Trimethylation
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Transcription, DNA-templated
Rhythmic Process
Cellular Response To Hypoxia
Pathways
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
RNA Polymerase I Promoter Escape
Transcriptional Regulation by E2F6
PKMTs methylate histone lysines
SIRT1 negatively regulates rRNA expression
Drugs
Diseases
GWAS
Metabolite levels (
23823483
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
46 interacting genes:
ADAMTSL4
ADNP2
ARL5A
ATXN7L2
AURKA
AURKB
BARD1
CACNB4
CBX1
CBX5
CDC42
DNMT3B
DSN1
GDF15
H1-4
H3-4
H3C1
H4C1
HECW2
HIPK2
HTR2C
KLF11
L3MBTL1
LAP3
LBR
LRIF1
MGA
MIS12
MKI67
MRPL12
NSD3
NSL1
PIM1
PRR14
RAD54L2
SP100
STK16
SUV39H1
TAF4
TRIM24
TRIM28
VHL
ZNF10
ZNF280C
ZNF280D
ZNF496
138 interacting genes:
ATE1
ATF3
ATP6V1B1
BAHD1
BCL11B
C4orf17
C8orf74
CBX1
CBX3
CBX4
CBX5
CDC23
CDCA4
CDCA7L
CEP70
CFAP100
CLK3
CRBN
CREBBP
CRELD2
DBF4B
DCAF8
DDB1
DNMT1
DNMT3A
DNMT3B
DVL3
ELOF1
EP300
ESR1
EZH2
FGD5
FOXR2
FRMD6
FUS
FYN
GOLGA6L9
GPATCH2L
GTF2H2C_2
GTPBP2
H3-3A
H3-4
H3-5
H3C1
H3C15
HDAC1
HDAC2
HDAC3
HDAC5
HOOK2
HOXA1
HOXC4
ID1
ID2
IGFBP4
IL16
ING4
INTS2
KDM1A
KLF15
KLHDC4
KLHL20
KRTAP10-7
KRTAP10-8
LDHAL6B
LENG8
LHX8
LINC02875
LNX1
LOXL4
LZTS2
MALT1
MBD1
MBD4
MCRS1
MSANTD3
MTF2
MTO1
MYOD1
NR1H2
NR1H3
ODAD3
OPA3
PADI6
PHF19
PML
PNKP
PPP1R16A
PRIM2
PRMT6
PSMC1
RASSF1
RASSF2
RB1
RBBP4
RBBP7
RBL1
RBL2
RIN3
RRP8
RSPO2
RUNX1
SBF1
SLFN12
SMAD1
SMAD5
SPATA24
SPRED1
SPSB1
SRGAP3
STX11
STX19
TEKT4
TEX35
THRA
TMEM11
TNFAIP1
TNS2
TRIM41
U2AF1
WDFY3
WIZ
ZBTB2
ZBTB24
ZCCHC17
ZKSCAN5
ZNF165
ZNF417
ZNF436
ZNF438
ZNF451
ZNF557
ZNF581
ZNF649
ZNF670
ZNF829
ZRANB1
ZSCAN9
Entrez ID
11335
6839
HPRD ID
05130
02221
Ensembl ID
ENSG00000122565
ENSG00000101945
Uniprot IDs
A4D177
Q13185
O43463
PDB IDs
2L11
3DM1
3KUP
3TZD
5T1I
6HW2
3MTS
Enriched GO Terms of Interacting Partners
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