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HTR2C and TMEM147
Data Source:
BioGRID
(two hybrid)
HTR2C
TMEM147
Description
5-hydroxytryptamine receptor 2C
transmembrane protein 147
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Dendrite
Synapse
G Protein-coupled Serotonin Receptor Complex
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Membrane
Protein-containing Complex
Molecular Function
Gq/11-coupled Serotonin Receptor Activity
G Protein-coupled Serotonin Receptor Activity
Protein Binding
Neurotransmitter Receptor Activity
Identical Protein Binding
Serotonin Binding
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding
Protein Binding
Biological Process
Behavioral Fear Response
Cellular Calcium Ion Homeostasis
G Protein-coupled Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Phospholipase C-activating Serotonin Receptor Signaling Pathway
Chemical Synaptic Transmission
Locomotory Behavior
Feeding Behavior
Positive Regulation Of Phosphatidylinositol Biosynthetic Process
CGMP-mediated Signaling
Regulation Of Nervous System Process
Regulation Of Appetite
Response To Drug
Regulation Of Corticotropin-releasing Hormone Secretion
Positive Regulation Of Fat Cell Differentiation
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
G Protein-coupled Serotonin Receptor Signaling Pathway
Pathways
Serotonin receptors
G alpha (q) signalling events
Drugs
Tramadol
Ziprasidone
Methysergide
Cabergoline
Amitriptyline
Olanzapine
Clozapine
Mirtazapine
Loxapine
Promazine
Cyproheptadine
Imipramine
Fluoxetine
Chlorpromazine
Chlorpromazine
Haloperidol
Nortriptyline
Amoxapine
Fenfluramine
Lisuride
Fluphenazine
Trazodone
Ergotamine
Apomorphine
Paroxetine
Trimipramine
Risperidone
Propiomazine
Minaprine
Cyclobenzaprine
Maprotiline
Ergoloid mesylate
Tegaserod
Doxepin
Nefazodone
Desipramine
Escitalopram
Pergolide
Dexfenfluramine
Bromocriptine
Ketamine
Quetiapine
Aripiprazole
Chlorprothixene
Clomipramine
Paliperidone
Yohimbine
Methotrimeprazine
Midomafetamine
4-Bromo-2,5-dimethoxyphenethylamine
Lorcaserin
Dapoxetine
Lofexidine
Epicept NP-1
Sertindole
Mianserin
Pizotifen
Asenapine
Ocaperidone
Dotarizine
Deramciclane
Agomelatine
Esmirtazapine
Captodiame
Etoperidone
Lorpiprazole
Setiptiline
Dihydroergocornine
m-Chlorophenylpiperazine
Gilteritinib
Sarpogrelate
Eplivanserin
Tiapride
Dihydroergocristine
2,5-Dimethoxy-4-ethylthioamphetamine
Aripiprazole lauroxil
Diseases
GWAS
Interacting Genes
34 interacting genes:
APBA1
ARRB2
ATP2B3
ATP6AP2
ATP6V0C
C4orf3
CALM1
CBX3
CNIH1
CRELD1
DLG4
EMP1
ERG28
GHITM
GJA1
GNAQ
GPR37
GPRC5B
LIN7C
MFSD14A
MPDZ
PLP1
RTN4
SGCB
SLC29A1
SLC39A1
SLC39A9
SNTA1
SPNS1
TM9SF2
TMBIM6
TMEM147
TMEM94
TPI1
54 interacting genes:
ABHD16A
ABI3
CD40
CD79A
CLDN7
CLN8
CLRN1
CREB3L1
CXCR2
DPM3
EBP
EFNA4
ENPP4
F11R
FFAR2
GJA8
GLP1R
GOLM1
GPR101
GPR37L1
GPR42
GPR61
HTR2C
IL3RA
KASH5
LDLRAD1
LEUTX
LHFPL2
MTIF3
MUC1
PACC1
PDCD1LG2
PSCA
PVR
RMDN3
RNF185
SCAMP4
SHISA3
SLC10A1
SLC12A7
SLC13A4
SLC22A1
SLC22A2
SUSD3
SYNE4
TACR1
TEX29
TMEM14B
TMEM237
TMEM248
TMEM252
TMEM42
TMEM52B
TSPAN12
Entrez ID
3358
10430
HPRD ID
02429
17633
Ensembl ID
ENSG00000147246
ENSG00000105677
Uniprot IDs
K9J958
P28335
Q9BVK8
PDB IDs
6BQG
6BQH
6W6L
Enriched GO Terms of Interacting Partners
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