HTR2C and CNIH1

Data Source:
BioGRID (two hybrid)

		HTR2C	CNIH1
Description		5-hydroxytryptamine receptor 2C	cornichon family AMPA receptor auxiliary protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse G Protein-coupled Serotonin Receptor Complex	Golgi Membrane Endoplasmic Reticulum Membrane ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Gq/11-coupled Serotonin Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Identical Protein Binding Serotonin Binding 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding	Protein Binding
	Biological Process	Behavioral Fear Response Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Locomotory Behavior Feeding Behavior Positive Regulation Of Phosphatidylinositol Biosynthetic Process CGMP-mediated Signaling Regulation Of Nervous System Process Regulation Of Appetite Response To Drug Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Fat Cell Differentiation Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Signaling Pathway	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Immune Response Signal Transduction COPII Vesicle Coating
Pathways		Serotonin receptors G alpha (q) signalling events	COPII-mediated vesicle transport Cargo concentration in the ER
Drugs		Tramadol Ziprasidone Methysergide Cabergoline Amitriptyline Olanzapine Clozapine Mirtazapine Loxapine Promazine Cyproheptadine Imipramine Fluoxetine Chlorpromazine Chlorpromazine Haloperidol Nortriptyline Amoxapine Fenfluramine Lisuride Fluphenazine Trazodone Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Propiomazine Minaprine Cyclobenzaprine Maprotiline Ergoloid mesylate Tegaserod Doxepin Nefazodone Desipramine Escitalopram Pergolide Dexfenfluramine Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Clomipramine Paliperidone Yohimbine Methotrimeprazine Midomafetamine 4-Bromo-2,5-dimethoxyphenethylamine Lorcaserin Dapoxetine Lofexidine Epicept NP-1 Sertindole Mianserin Pizotifen Asenapine Ocaperidone Dotarizine Deramciclane Agomelatine Esmirtazapine Captodiame Etoperidone Lorpiprazole Setiptiline Dihydroergocornine m-Chlorophenylpiperazine Gilteritinib Sarpogrelate Eplivanserin Tiapride Dihydroergocristine 2,5-Dimethoxy-4-ethylthioamphetamine Aripiprazole lauroxil
Diseases
GWAS			Monobrow thickness ( 26926045)
Interacting Genes		34 interacting genes: APBA1 ARRB2 ATP2B3 ATP6AP2 ATP6V0C C4orf3 CALM1 CBX3 CNIH1 CRELD1 DLG4 EMP1 ERG28 GHITM GJA1 GNAQ GPR37 GPRC5B LIN7C MFSD14A MPDZ PLP1 RTN4 SGCB SLC29A1 SLC39A1 SLC39A9 SNTA1 SPNS1 TM9SF2 TMBIM6 TMEM147 TMEM94 TPI1	29 interacting genes: AQP6 BIK CD53 CD79A CLDN7 CPLX4 CYB5R3 ERGIC3 EVI2B FAM209A FCER1G FFAR2 GPR152 GPX8 HTR2C LEUTX LRRC59 MCEMP1 MFF MRM1 OPRM1 RNF24 SHISA4 SLC10A6 SLC18A1 SLC22A23 SLC35C2 SMIM3 TMEM52B
Entrez ID		3358	10175
HPRD ID		02429	16730
Ensembl ID		ENSG00000147246	ENSG00000100528
Uniprot IDs		K9J958 P28335	B2R4P1 O95406
PDB IDs		6BQG 6BQH
Enriched GO Terms of Interacting Partners?
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