DNAJA1 and CD58

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DNAJA1	CD58
Description		DnaJ heat shock protein family (Hsp40) member A1	CD58 molecule
Image
GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	G Protein-coupled Receptor Binding ATPase Activator Activity Protein Binding ATP Binding Hsp70 Protein Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding C3HC4-type RING Finger Domain Binding	Signaling Receptor Binding Protein Binding
	Biological Process	Protein Folding Response To Unfolded Protein Spermatogenesis Response To Heat Flagellated Sperm Motility Androgen Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of ATPase Activity DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Toxin Transport Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway	Positive Regulation Of Interleukin-8 Production Heterotypic Cell-cell Adhesion Neutrophil Degranulation Leukocyte Migration Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Cell-cell Adhesion
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR)	Cell surface interactions at the vascular wall Neutrophil degranulation
Drugs
Diseases
GWAS			Multiple sclerosis ( 31604244 22190364 21244703 24076602 19525953 19525955 21833088 27386562) Primary biliary cholangitis ( 28425483) Systemic lupus erythematosus ( 33536424)
Interacting Genes		24 interacting genes: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR ERG FZR1 HIVEP1 HMGCL HSPA8 LINC01554 LSM2 NELFCD NUDT3 PAXIP1 PGR PTEN PTTG1 SUMO2 SUMO4 TM4SF1 TXN	4 interacting genes: APP CD2 DNAJA1 HERPUD1
Entrez ID		3301	965
HPRD ID		04159	01081
Ensembl ID		ENSG00000086061	ENSG00000116815
Uniprot IDs		B7Z5C0 P31689	P19256
PDB IDs		2LO1 2M6Y 6E8M	1CCZ 1CI5 1QA9
Enriched GO Terms of Interacting Partners?
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