DNAJA1 and BCS1L

Data Source:
BioGRID (two hybrid)

		DNAJA1	BCS1L
Description		DnaJ heat shock protein family (Hsp40) member A1	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex III Integral Component Of Membrane
	Molecular Function	G Protein-coupled Receptor Binding ATPase Activator Activity Protein Binding ATP Binding Hsp70 Protein Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding C3HC4-type RING Finger Domain Binding	Protein Binding ATP Binding ATPase Activity
	Biological Process	Protein Folding Response To Unfolded Protein Spermatogenesis Response To Heat Flagellated Sperm Motility Androgen Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of ATPase Activity DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Toxin Transport Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway	Mitochondrion Organization Protein Insertion Into Mitochondrial Inner Membrane From Matrix Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Cytochrome C Oxidase Assembly Mitochondrial Respiratory Chain Complex III Assembly
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR)	Mitochondrial protein import
Drugs
Diseases			Bjornstad syndrome Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS			Male-pattern baldness ( 28196072)
Interacting Genes		24 interacting genes: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR ERG FZR1 HIVEP1 HMGCL HSPA8 LINC01554 LSM2 NELFCD NUDT3 PAXIP1 PGR PTEN PTTG1 SUMO2 SUMO4 TM4SF1 TXN	3 interacting genes: DDX24 DNAJA1 MTDH
Entrez ID		3301	617
HPRD ID		04159	04708
Ensembl ID		ENSG00000086061	ENSG00000074582
Uniprot IDs		B7Z5C0 P31689	A0A024R445 A8JZZ8 Q9Y276
PDB IDs		2LO1 2M6Y 6E8M
Enriched GO Terms of Interacting Partners?
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