DNAJA1 and HMGCL

Data Source:
BioGRID (two hybrid)

		DNAJA1	HMGCL
Description		DnaJ heat shock protein family (Hsp40) member A1	3-hydroxy-3-methylglutaryl-CoA lyase
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GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Microtubule Cytoskeleton Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome Cytoplasmic Side Of Endoplasmic Reticulum Membrane	Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Protein-containing Complex
	Molecular Function	G Protein-coupled Receptor Binding ATPase Activator Activity Protein Binding ATP Binding Hsp70 Protein Binding Tat Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Chaperone Binding C3HC4-type RING Finger Domain Binding	Fatty-acyl-CoA Binding Magnesium Ion Binding Hydroxymethylglutaryl-CoA Lyase Activity Structural Molecule Activity Manganese Ion Binding Carboxylic Acid Binding Metal Ion Binding
	Biological Process	Protein Folding Response To Unfolded Protein Spermatogenesis Response To Heat Flagellated Sperm Motility Androgen Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Positive Regulation Of ATPase Activity DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of JUN Kinase Activity Regulation Of Protein Transport Protein Localization To Mitochondrion Toxin Transport Negative Regulation Of Establishment Of Protein Localization To Mitochondrion Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway	Liver Development Leucine Catabolic Process Protein Targeting To Peroxisome Lipid Metabolic Process Acyl-CoA Metabolic Process Mitochondrion Organization Response To Nutrient Response To Starvation Ketone Body Biosynthetic Process Response To Fatty Acid
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR)	Synthesis of Ketone Bodies Peroxisomal protein import Peroxisomal protein import
Drugs			3-hydroxyglutaric acid
Diseases			3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
GWAS			High light scatter reticulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Red blood cell count ( 32888494) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		24 interacting genes: ARL4D BCS1L BRCA1 CAV2 CD58 CDC16 CFTR ERG FZR1 HIVEP1 HMGCL HSPA8 LINC01554 LSM2 NELFCD NUDT3 PAXIP1 PGR PTEN PTTG1 SUMO2 SUMO4 TM4SF1 TXN	9 interacting genes: ADAMTS10 ARL6IP1 DNAJA1 GTF2B HES1 HSD17B10 MS4A7 PEX5 RNF126
Entrez ID		3301	3155
HPRD ID		04159	02003
Ensembl ID		ENSG00000086061	ENSG00000117305
Uniprot IDs		B7Z5C0 P31689	P35914
PDB IDs		2LO1 2M6Y 6E8M	2CW6 3MP3 3MP4 3MP5
Enriched GO Terms of Interacting Partners?
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