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DNAJA1 and PTTG1
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
DNAJA1
PTTG1
Description
DnaJ heat shock protein family (Hsp40) member A1
PTTG1 regulator of sister chromatid separation, securin
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Mitochondrion
Cytosol
Microtubule Cytoskeleton
Membrane
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Cytoplasmic Side Of Endoplasmic Reticulum Membrane
Nucleus
Cytoplasm
Cytosol
Molecular Function
G Protein-coupled Receptor Binding
ATPase Activator Activity
Protein Binding
ATP Binding
Hsp70 Protein Binding
Tat Protein Binding
Ubiquitin Protein Ligase Binding
Metal Ion Binding
Low-density Lipoprotein Particle Receptor Binding
Unfolded Protein Binding
Chaperone Binding
C3HC4-type RING Finger Domain Binding
Cysteine-type Endopeptidase Inhibitor Activity
Protein Binding
SH3 Domain Binding
Biological Process
Protein Folding
Response To Unfolded Protein
Spermatogenesis
Response To Heat
Flagellated Sperm Motility
Androgen Receptor Signaling Pathway
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of ATPase Activity
DNA Damage Response, Detection Of DNA Damage
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of JUN Kinase Activity
Regulation Of Protein Transport
Protein Localization To Mitochondrion
Toxin Transport
Negative Regulation Of Establishment Of Protein Localization To Mitochondrion
Negative Regulation Of Nitrosative Stress-induced Intrinsic Apoptotic Signaling Pathway
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Spermatogenesis
Negative Regulation Of Endopeptidase Activity
Anaphase-promoting Complex-dependent Catabolic Process
Homologous Chromosome Segregation
Chromosome Organization
Cell Division
Negative Regulation Of Mitotic Sister Chromatid Separation
Pathways
HSP90 chaperone cycle for steroid hormone receptors (SHR)
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Drugs
Diseases
GWAS
Dermatomyositis or juvenile dermatomyositis (
26362759
)
Insulin-related traits (
22791750
)
Sjögren's syndrome (
24097067
)
Systemic lupus erythematosus (
21408207
28714469
19838195
)
Systemic lupus erythematosus or rheumatoid arthritis (
27193031
)
Interacting Genes
24 interacting genes:
ARL4D
BCS1L
BRCA1
CAV2
CD58
CDC16
CFTR
ERG
FZR1
HIVEP1
HMGCL
HSPA8
LINC01554
LSM2
NELFCD
NUDT3
PAXIP1
PGR
PTEN
PTTG1
SUMO2
SUMO4
TM4SF1
TXN
23 interacting genes:
ANAPC11
ANAPC2
AURKA
CAMK2A
CDC20
CDC27
CDC34
CDK1
CRK
CUL1
DNAJA1
FZR1
PLCG2
PPP2R2D
PPP2R5A
PRKN
PTTG1IP
RPS10
TP53
UBE2C
UBE2N
UBE4A
XRCC6
Entrez ID
3301
9232
HPRD ID
04159
04998
Ensembl ID
ENSG00000086061
ENSG00000164611
Uniprot IDs
B7Z5C0
P31689
O95997
Q6IAL9
PDB IDs
2LO1
2M6Y
6E8M
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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