HCRTR2 and HCRT

Data Source:
HPRD (in vivo)

		HCRTR2	HCRT
Description		hypocretin receptor 2	hypocretin neuropeptide precursor
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Synapse	Extracellular Region Rough Endoplasmic Reticulum Synaptic Vesicle Secretory Granule Perinuclear Region Of Cytoplasm Postsynapse
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity Orexin Receptor Activity Peptide Hormone Binding	Neuropeptide Hormone Activity Type 1 Hypocretin Receptor Binding Type 2 Hypocretin Receptor Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Circadian Sleep/wake Cycle, Wakefulness Circadian Sleep/wake Cycle Process Regulation Of Cytosolic Calcium Ion Concentration	Temperature Homeostasis G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Negative Regulation Of DNA Replication Sleep Response To Starvation Eating Behavior Negative Regulation Of Potassium Ion Transport Regulation Of Neurotransmitter Secretion Positive Regulation Of Calcium Ion Transport Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Positive Regulation Of Cold-induced Thermogenesis
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs		Suvorexant Lemborexant	Pidolic acid
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Chronotype ( 30696823 27494321) Excessive daytime sleepiness ( 27992416) Fasting glucose change (long-term) ( 31263163) HIV-1 control ( 20041166) Menarche (age at onset) ( 25231870) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600 27494321) Severity of nausea and vomiting of pregnancy ( 29563502) Sleep duration (short sleep) ( 30846698) Sleep traits (multi-trait analysis) ( 27992416)
Interacting Genes		2 interacting genes: CD200 HCRT	3 interacting genes: HCRTR1 HCRTR2 NPFFR2
Entrez ID		3062	3060
HPRD ID		08374	03836
Ensembl ID		ENSG00000137252	ENSG00000161610
Uniprot IDs		O43614 S4X0W3	O43612
PDB IDs		4S0V 5WQC 5WS3 6TPG 6TPJ 6TPN	1CQ0 1R02 1UVQ 1WSO
Enriched GO Terms of Interacting Partners?
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