HCRT and HCRTR2

Data Source:
HPRD (in vivo)

		HCRT	HCRTR2
Description		hypocretin neuropeptide precursor	hypocretin receptor 2
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GO Annotations	Cellular Component	Extracellular Region Rough Endoplasmic Reticulum Synaptic Vesicle Secretory Granule Perinuclear Region Of Cytoplasm Postsynapse	Plasma Membrane Integral Component Of Plasma Membrane Synapse
	Molecular Function	Neuropeptide Hormone Activity Type 1 Hypocretin Receptor Binding Type 2 Hypocretin Receptor Binding	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity Orexin Receptor Activity Peptide Hormone Binding
	Biological Process	Temperature Homeostasis G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Negative Regulation Of DNA Replication Sleep Response To Starvation Eating Behavior Negative Regulation Of Potassium Ion Transport Regulation Of Neurotransmitter Secretion Positive Regulation Of Calcium Ion Transport Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Positive Regulation Of Cold-induced Thermogenesis	G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Circadian Sleep/wake Cycle, Wakefulness Circadian Sleep/wake Cycle Process Regulation Of Cytosolic Calcium Ion Concentration
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs		Pidolic acid	Suvorexant Lemborexant
Diseases
GWAS			Blood urea nitrogen levels ( 31152163) Chronotype ( 30696823 27494321) Excessive daytime sleepiness ( 27992416) Fasting glucose change (long-term) ( 31263163) HIV-1 control ( 20041166) Menarche (age at onset) ( 25231870) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600 27494321) Severity of nausea and vomiting of pregnancy ( 29563502) Sleep duration (short sleep) ( 30846698) Sleep traits (multi-trait analysis) ( 27992416)
Interacting Genes		3 interacting genes: HCRTR1 HCRTR2 NPFFR2	2 interacting genes: CD200 HCRT
Entrez ID		3060	3062
HPRD ID		03836	08374
Ensembl ID		ENSG00000161610	ENSG00000137252
Uniprot IDs		O43612	O43614 S4X0W3
PDB IDs		1CQ0 1R02 1UVQ 1WSO	4S0V 5WQC 5WS3 6TPG 6TPJ 6TPN
Enriched GO Terms of Interacting Partners?
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