HCRT and HCRTR1

Data Source:
HPRD (in vitro, in vivo)

		HCRT	HCRTR1
Description		hypocretin neuropeptide precursor	hypocretin receptor 1
Image
GO Annotations	Cellular Component	Extracellular Region Rough Endoplasmic Reticulum Synaptic Vesicle Secretory Granule Perinuclear Region Of Cytoplasm Postsynapse	Plasma Membrane Integral Component Of Plasma Membrane Synapse
	Molecular Function	Neuropeptide Hormone Activity Type 1 Hypocretin Receptor Binding Type 2 Hypocretin Receptor Binding	G Protein-coupled Receptor Activity Protein Binding Orexin Receptor Activity Peptide Hormone Binding
	Biological Process	Temperature Homeostasis G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Negative Regulation Of DNA Replication Sleep Response To Starvation Eating Behavior Negative Regulation Of Potassium Ion Transport Regulation Of Neurotransmitter Secretion Positive Regulation Of Calcium Ion Transport Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Positive Regulation Of Cold-induced Thermogenesis	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of ERK1 And ERK2 Cascade
Pathways		Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events	Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
Drugs		Pidolic acid	Suvorexant Lemborexant
Diseases
GWAS			Asthma ( 31959851) Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) General cognitive ability ( 29844566)
Interacting Genes		3 interacting genes: HCRTR1 HCRTR2 NPFFR2	4 interacting genes: ARRB1 ARRB2 CNR1 HCRT
Entrez ID		3060	3061
HPRD ID		03836	03863
Ensembl ID		ENSG00000161610	ENSG00000121764
Uniprot IDs		O43612	A6NMV7 O43613
PDB IDs		1CQ0 1R02 1UVQ 1WSO	4ZJ8 4ZJC 6TO7 6TOD 6TOS 6TOT 6TP3 6TP4 6TP6 6TQ4 6TQ6 6TQ7 6TQ9 6V9S
Enriched GO Terms of Interacting Partners?
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