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AMFR and DERL1
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down)
AMFR
DERL1
Description
autocrine motility factor receptor
derlin 1
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Cytosol
Membrane
Integral Component Of Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Dendrite
Growth Cone
Protein-containing Complex
Derlin-1 Retrotranslocation Complex
Neuronal Cell Body
Endoplasmic Reticulum Quality Control Compartment
Perinuclear Region Of Cytoplasm
Hrd1p Ubiquitin Ligase ERAD-L Complex
Early Endosome
Late Endosome
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Derlin-1-VIMP Complex
Derlin-1 Retrotranslocation Complex
Endoplasmic Reticulum Quality Control Compartment
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Protein-macromolecule Adaptor Activity
Ubiquitin-ubiquitin Ligase Activity
Signaling Receptor Activity
Identical Protein Binding
Ubiquitin Binding
Metal Ion Binding
Chaperone Binding
Ubiquitin Protein Ligase Activity
BAT3 Complex Binding
Ubiquitin-specific Protease Binding
Protease Binding
Signal Recognition Particle Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Signaling Receptor Activity
MHC Class I Protein Binding
Identical Protein Binding
Protein-containing Complex Binding
ATPase Binding
Misfolded Protein Binding
Ubiquitin-specific Protease Binding
Biological Process
Protein Polyubiquitination
Protein Folding
Ubiquitin-dependent Protein Catabolic Process
Signal Transduction
Aging
Learning Or Memory
Wnt Signaling Pathway
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Protein Binding
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Endoplasmic Reticulum Mannose Trimming
Regulation Of SREBP Signaling Pathway
Protein Folding
Response To Unfolded Protein
Viral Process
Protein Ubiquitination
Ubiquitin-dependent ERAD Pathway
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Positive Regulation Of Protein Ubiquitination
Protein Destabilization
Positive Regulation Of Protein Binding
ERAD Pathway
Establishment Of Protein Localization
Transmembrane Transport
ER-associated Misfolded Protein Catabolic Process
Pathways
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
ER Quality Control Compartment (ERQC)
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Defective CFTR causes cystic fibrosis
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS
Apolipoprotein A1 levels (
32203549
)
Breast cancer (
29059683
)
Mean reticulocyte volume (
32888494
)
Metabolite levels (
23823483
)
Interacting Genes
28 interacting genes:
BAG6
CRMP1
CYP2E1
DERL1
DHFR
GPI
HERPUD1
HTT
KPNB1
MGRN1
SOD1
TOM1L1
TRIM25
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2G1
UBE2G2
UBE2K
UBE2N
UBE2T
UBE2W
UBL4A
UFD1
USP13
VCP
33 interacting genes:
ABHD4
AMFR
APP
AQP6
CFTR
CIAO2A
FCRL4
FFAR2
GAD2
HLA-A
KASH5
LMNA
LNX1
MELTF
REEP4
RETREG3
RHO
SCN3B
SELENOS
SLC10A1
SLC10A6
SLC30A8
SLC7A14
SLC7A8
TCF25
TEX44
TMED8
TMEM31
TMX2
TRIM32
UBE2J1
UBXN6
VCP
Entrez ID
267
79139
HPRD ID
09130
12302
Ensembl ID
ENSG00000159461
ENSG00000136986
Uniprot IDs
A0A024R6R5
Q9UKV5
A0A024R9G3
E5RGY0
Q9BUN8
PDB IDs
2EJS
2LVN
2LVO
2LVP
2LVQ
2LXH
2LXP
3FSH
3H8K
3TIW
4G3O
4LAD
5GLF
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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