DERL1 and TMED8

Data Source:
BioGRID (two hybrid)

		DERL1	TMED8
Description		derlin 1	transmembrane p24 trafficking protein family member 8
Image			No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	Protease Binding Signal Recognition Particle Binding Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding Protein-containing Complex Binding ATPase Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding	Protein Binding
	Biological Process	Protein Folding Response To Unfolded Protein Viral Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Protein Binding ERAD Pathway Establishment Of Protein Localization Transmembrane Transport ER-associated Misfolded Protein Catabolic Process
Pathways		ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective CFTR causes cystic fibrosis E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		33 interacting genes: ABHD4 AMFR APP AQP6 CFTR CIAO2A FCRL4 FFAR2 GAD2 HLA-A KASH5 LMNA LNX1 MELTF REEP4 RETREG3 RHO SCN3B SELENOS SLC10A1 SLC10A6 SLC30A8 SLC7A14 SLC7A8 TCF25 TEX44 TMED8 TMEM31 TMX2 TRIM32 UBE2J1 UBXN6 VCP	32 interacting genes: ADTRP AMIGO2 APOL2 ARL6IP1 C10orf67 CIAO2A CMTM5 CMTM6 CYB561D1 DEFB129 DERL1 DGAT2L6 EI24 H4C7 LAPTM4A MDK MMGT1 MRPL41 MRPS18B MTIF3 NDUFA12 REEP6 SERP2 STX8 SUSD3 TMEM115 TMEM121 TMEM218 TMEM254 TRAM1L1 UNC50 ZDHHC16
Entrez ID		79139	283578
HPRD ID		12302	18201
Ensembl ID		ENSG00000136986	ENSG00000100580
Uniprot IDs		A0A024R9G3 E5RGY0 Q9BUN8	Q6PL24
PDB IDs		5GLF
Enriched GO Terms of Interacting Partners?
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