DERL1 and UBXN6

Data Source:
BioGRID (pull down)

		DERL1	UBXN6
Description		derlin 1	UBX domain protein 6
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GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase ERAD-L Complex Early Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex Endoplasmic Reticulum Quality Control Compartment	Nucleus Cytoplasm Lysosomal Membrane Endosome Microtubule Organizing Center Cytosol Extrinsic Component Of Membrane Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Protease Binding Signal Recognition Particle Binding Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity MHC Class I Protein Binding Identical Protein Binding Protein-containing Complex Binding ATPase Binding Misfolded Protein Binding Ubiquitin-specific Protease Binding	Protein Binding
	Biological Process	Protein Folding Response To Unfolded Protein Viral Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Protein Binding ERAD Pathway Establishment Of Protein Localization Transmembrane Transport ER-associated Misfolded Protein Catabolic Process	Macroautophagy Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway ERAD Pathway
Pathways		ABC-family proteins mediated transport N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective CFTR causes cystic fibrosis E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483)	Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Multiple sclerosis ( 31604244) Red blood cell count ( 32888494)
Interacting Genes		33 interacting genes: ABHD4 AMFR APP AQP6 CFTR CIAO2A FCRL4 FFAR2 GAD2 HLA-A KASH5 LMNA LNX1 MELTF REEP4 RETREG3 RHO SCN3B SELENOS SLC10A1 SLC10A6 SLC30A8 SLC7A14 SLC7A8 TCF25 TEX44 TMED8 TMEM31 TMX2 TRIM32 UBE2J1 UBXN6 VCP	20 interacting genes: APP DAZAP2 DERL1 FAM168A GSK3B MAGEA4 MCL1 NLGN3 PLEKHB2 SMURF1 SUSD6 SVIP TRIM39 UBC UBXN10 UBXN2A UBXN2B UFD1 VCP YOD1
Entrez ID		79139	80700
HPRD ID		12302	18253
Ensembl ID		ENSG00000136986	ENSG00000167671
Uniprot IDs		A0A024R9G3 E5RGY0 Q9BUN8	Q9BZV1
PDB IDs		5GLF	6SAP
Enriched GO Terms of Interacting Partners?
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