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HEY1 and PRKD2
Data Source:
BioGRID
(two hybrid)
HEY1
PRKD2
Description
hes related family bHLH transcription factor with YRPW motif 1
protein kinase D2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Dimerization Activity
Sequence-specific Double-stranded DNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Calcium-dependent Protein Kinase C Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Pulmonary Valve Morphogenesis
Atrioventricular Valve Formation
Endocardial Cushion Morphogenesis
Cardiac Ventricle Morphogenesis
Regulation Of Transcription By RNA Polymerase II
Notch Signaling Pathway
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Dorsal Aorta Morphogenesis
Umbilical Cord Morphogenesis
Negative Regulation Of Neuron Differentiation
Negative Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Neurogenesis
Cardiac Epithelial To Mesenchymal Transition
Heart Trabecula Formation
Cardiac Septum Morphogenesis
Ventricular Septum Morphogenesis
Labyrinthine Layer Blood Vessel Development
Arterial Endothelial Cell Differentiation
Notch Signaling Involved In Heart Development
Negative Regulation Of Biomineral Tissue Development
Cellular Response To Glucocorticoid Stimulus
Circulatory System Development
Negative Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation
Regulation Of Vasculogenesis
Angiogenesis
Positive Regulation Of Endothelial Cell Proliferation
Adaptive Immune Response
Protein Phosphorylation
Cell Adhesion
Cell Death
Positive Regulation Of Endothelial Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Sphingolipid Biosynthetic Process
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of CREB Transcription Factor Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Intracellular Signal Transduction
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Angiogenesis
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Endothelial Tube Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Protein Kinase D Signaling
Positive Regulation Of Histone Deacetylase Activity
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of Endothelial Cell Chemotaxis
Pathways
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
RUNX2 regulates osteoblast differentiation
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS
Chronic lymphocytic leukemia (
18758461
28165464
)
Coronary artery disease (
29212778
)
Eosinophil counts (
32888494
)
Heel bone mineral density (
30598549
)
Post bronchodilator FEV1 (
26634245
)
Primary sclerosing cholangitis (
23603763
27992413
)
Interacting Genes
22 interacting genes:
ARNT
CREBZF
DAZAP2
FBXW7
FOXH1
GATA1
HES1
HEY2
KRTAP6-2
LAPTM5
MDM2
MYOD1
NTRK3
PITX2
PLEKHB2
PRKD2
SKIL
SMAD3
SMAD9
TENT5D
TP53
YTHDF1
17 interacting genes:
CASK
DST
GLRX3
GORASP1
GRIP1
HDAC7
HEY1
IFNAR1
MTF2
PDLIM7
PFDN1
PSG3
RARB
RRBP1
RXRA
SNRNP70
TGOLN2
Entrez ID
23462
25865
HPRD ID
04260
09523
Ensembl ID
ENSG00000164683
ENSG00000105287
Uniprot IDs
B4DEI9
Q9Y5J3
Q9BZL6
PDB IDs
2DB7
2COA
3BGM
4NNX
4NNY
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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