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ERCC3 and GTF2E2
Data Source:
HPRD
(in vitro)
ERCC3
GTF2E2
Description
ERCC excision repair 3, TFIIH core complex helicase subunit
general transcription factor IIE subunit 2
Image
GO Annotations
Cellular Component
Nucleotide-excision Repair Factor 3 Complex
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIH Holo Complex
Transcription Preinitiation Complex
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIE Complex
Cytosol
Nuclear Speck
Molecular Function
DNA Binding
Damaged DNA Binding
Helicase Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Transcription Factor Binding
ATPase Activity
3'-5' DNA Helicase Activity
Protein N-terminus Binding
DNA Binding
RNA Binding
Protein Binding
RNA Polymerase II General Transcription Initiation Factor Activity
Biological Process
Nucleotide-excision Repair, DNA Duplex Unwinding
DNA Topological Change
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Apoptotic Process
Response To Oxidative Stress
Protein Localization
Response To UV
Viral Process
Nucleotide-excision Repair, DNA Incision
Hair Cell Differentiation
Positive Regulation Of Apoptotic Process
Embryonic Organ Development
Global Genome Nucleotide-excision Repair
Regulation Of Mitotic Cell Cycle Phase Transition
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
SnRNA Transcription By RNA Polymerase II
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
RNA Polymerase II Pre-transcription Events
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Cognitive performance (
20125193
)
Mean corpuscular volume (
32888494
)
Metabolite levels (X-11787) (
23934736
)
Interacting Genes
37 interacting genes:
ADAMTSL4
AR
BCR
BLZF1
CCNC
CCNH
CDC42
CDK7
CDK8
CEP70
CEP76
E2F1
ERCC2
GOLGA2
GTF2E1
GTF2E2
GTF2H1
GTF2H2
GTF2H3
GTF2H4
GTF2H5
KPNA3
MAGED1
MCF2
MNAT1
MSANTD2
PSMC5
RAD52
ROPN1
SNW1
SRPK2
TP53
TRIM14
TRIM27
XIAP
XPC
ZSCAN1
26 interacting genes:
APP
ATF7IP
CCNH
CDK7
ERCC3
ERCC6
EXOC8
FOS
GTF2A1
GTF2B
GTF2E1
GTF2F1
GTF2F2
GTF2H1
JUN
KAT5
KLF5
MCC
MDM2
MNAT1
NUP62
PICK1
SND1
SUPT16H
TBP
XPA
Entrez ID
2071
2961
HPRD ID
00593
01800
Ensembl ID
ENSG00000163161
ENSG00000197265
Uniprot IDs
B3KRG2
B3KTH1
G3V1S1
P19447
P29084
PDB IDs
4ERN
5IVW
5IY6
5IY7
5IY8
5IY9
5OF4
6NMI
6O9L
6O9M
6RO4
1D8J
1D8K
5GPY
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
6O9L
Enriched GO Terms of Interacting Partners
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