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ERCC3 and MNAT1
Data Source:
HPRD
(in vitro, in vivo)
ERCC3
MNAT1
Description
ERCC excision repair 3, TFIIH core complex helicase subunit
MNAT1 component of CDK activating kinase
Image
GO Annotations
Cellular Component
Nucleotide-excision Repair Factor 3 Complex
Transcription Factor TFIIH Core Complex
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIH Holo Complex
Transcription Preinitiation Complex
Transcription Factor TFIIH Core Complex
Nucleoplasm
Transcription Factor TFIIH Holo Complex
Cyclin-dependent Protein Kinase Activating Kinase Holoenzyme Complex
CAK-ERCC2 Complex
Transcription Factor TFIIK Complex
Molecular Function
DNA Binding
Damaged DNA Binding
Helicase Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Transcription Factor Binding
ATPase Activity
3'-5' DNA Helicase Activity
Protein N-terminus Binding
Protein Binding
Zinc Ion Binding
Protein N-terminus Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Biological Process
Nucleotide-excision Repair, DNA Duplex Unwinding
DNA Topological Change
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Apoptotic Process
Response To Oxidative Stress
Protein Localization
Response To UV
Viral Process
Nucleotide-excision Repair, DNA Incision
Hair Cell Differentiation
Positive Regulation Of Apoptotic Process
Embryonic Organ Development
Global Genome Nucleotide-excision Repair
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Assembly
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Adult Heart Development
Ventricular System Development
Negative Regulation Of Apoptotic Process
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Smooth Muscle Cell Proliferation
Response To Calcium Ion
Protein-containing Complex Assembly
Negative Regulation Of DNA Helicase Activity
Pathways
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
Formation of RNA Pol II elongation complex
Formation of the Early Elongation Complex
Formation of HIV elongation complex in the absence of HIV Tat
Formation of the HIV-1 Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Tat-mediated elongation of the HIV-1 transcript
NoRC negatively regulates rRNA expression
Formation of Incision Complex in GG-NER
RNA Polymerase II Pre-transcription Events
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of DNA Repair Genes
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
mRNA Capping
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Pol II CTD phosphorylation and interaction with CE
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease (
29631575
)
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
Immune reponse to smallpox (secreted IFN-alpha) (
22610502
)
Refractive error (
32231278
)
Interacting Genes
37 interacting genes:
ADAMTSL4
AR
BCR
BLZF1
CCNC
CCNH
CDC42
CDK7
CDK8
CEP70
CEP76
E2F1
ERCC2
GOLGA2
GTF2E1
GTF2E2
GTF2H1
GTF2H2
GTF2H3
GTF2H4
GTF2H5
KPNA3
MAGED1
MCF2
MNAT1
MSANTD2
PSMC5
RAD52
ROPN1
SNW1
SRPK2
TP53
TRIM14
TRIM27
XIAP
XPC
ZSCAN1
48 interacting genes:
BEX3
BRCA1
CDK7
COPS6
DMAP1
E2F1
EEF1A1
ERCC2
ERCC3
ESR1
FOXP1
GOLGA2
GTF2E2
GTF2H1
GTF2H2
HPS6
LRIF1
MAGEC2
MAGEE2
MCM7
MDM4
MKRN3
MTA1
NKX3-1
POLR2A
POU2F1
POU2F2
POU5F1
RB1
RBM48
RNF32
RNF41
RNF7
SUPT5H
TET2
TP53
TRIM14
TRIM17
TRIM2
TRIM21
TRIM26
TRIM31
TRIM34
TRIM39
TRIM5
TRIM9
TRIML1
USP2
Entrez ID
2071
4331
HPRD ID
00593
04042
Ensembl ID
ENSG00000163161
ENSG00000020426
Uniprot IDs
B3KRG2
B3KTH1
G3V1S1
P19447
A0A024R669
A0A024R688
P51948
PDB IDs
4ERN
5IVW
5IY6
5IY7
5IY8
5IY9
5OF4
6NMI
6O9L
6O9M
6RO4
1G25
6NMI
6O9L
6O9M
6XBZ
6XD3
Enriched GO Terms of Interacting Partners
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