GTF2E2 and GTF2E1

Data Source:
HPRD (in vivo, in vitro)

		GTF2E2	GTF2E1
Description		general transcription factor IIE subunit 2	general transcription factor IIE subunit 1
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GO Annotations	Cellular Component	Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIE Complex Cytosol Nuclear Speck	Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIE Complex Cytosol Transcription Preinitiation Complex
	Molecular Function	DNA Binding RNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity	Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity Metal Ion Binding
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter SnRNA Transcription By RNA Polymerase II	Transcription Open Complex Formation At RNA Polymerase II Promoter Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Viral Process SnRNA Transcription By RNA Polymerase II
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
GWAS		Cognitive performance ( 20125193) Mean corpuscular volume ( 32888494) Metabolite levels (X-11787) ( 23934736)	Obesity-related traits ( 23251661)
Interacting Genes		26 interacting genes: APP ATF7IP CCNH CDK7 ERCC3 ERCC6 EXOC8 FOS GTF2A1 GTF2B GTF2E1 GTF2F1 GTF2F2 GTF2H1 JUN KAT5 KLF5 MCC MDM2 MNAT1 NUP62 PICK1 SND1 SUPT16H TBP XPA	34 interacting genes: APP CBFA2T2 CDK7 ERCC2 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E2 GTF2F1 GTF2F2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 IKBKG NRARP PCBD2 POLR2A SND1 SRPK2 TAF1 TAF11 TAF6 TBC1D21 TBP TCEA1 TLE5 TRIM15 TRIM24 TRIM29 ZBTB9 ZSCAN1
Entrez ID		2961	2960
HPRD ID		01800	01799
Ensembl ID		ENSG00000197265	ENSG00000153767
Uniprot IDs		P29084	P29083
PDB IDs		1D8J 1D8K 5GPY 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L	1VD4 2JTX 2RNQ 2RNR 5GPY 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L
Enriched GO Terms of Interacting Partners?
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