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SYNE4 and GADD45A
Data Source:
BioGRID
(two hybrid)
SYNE4
GADD45A
Description
spectrin repeat containing nuclear envelope family member 4
growth arrest and DNA damage inducible alpha
Image
GO Annotations
Cellular Component
Integral Component Of Nuclear Outer Membrane
Meiotic Nuclear Membrane Microtubule Tethering Complex
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
Molecular Function
Protein Binding
Protein Binding
Kinase Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Protein N-terminus Binding
Promoter-specific Chromatin Binding
Biological Process
Establishment Of Epithelial Cell Apical/basal Polarity
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Activation Of MAPKKK Activity
DNA Repair
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Centrosome Cycle
Negative Regulation Of Angiogenesis
Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein
Signal Transduction In Response To DNA Damage
Positive Regulation Of Apoptotic Process
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of JNK Cascade
Regulation Of Cell Cycle
Cellular Response To Mechanical Stimulus
Cellular Response To Ionizing Radiation
Mitotic Cell Cycle Arrest
Negative Regulation Of Protein Serine/threonine Kinase Activity
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS
Bone mineral density (hip) (
30172743
)
Mean corpuscular volume (
29403010
)
Offspring birth weight (
31043758
)
Optic disc area (
28073927
)
Optic disc size (
31809533
)
Platelet distribution width (
32888494
)
Red blood cell count (
32888494
)
Interacting Genes
56 interacting genes:
ABT1
ADIPOQ
BRICD5
C3orf52
CD47
CEP19
CLDN19
CLDN7
CLDN8
CLEC7A
CMTM5
CSGALNACT2
CSNK2B
CXCL9
DEFB121
ECE2
EDDM3B
EMP1
ENTPD3
FAM241B
FATE1
GADD45A
GSK3B
IGFBP5
ITM2B
KLHL12
KLRG1
KTN1
MALL
MARCHF2
NAGK
OCLN
OLFM4
OSTCP1
PAQR5
PLPP6
RIPPLY2
RPS6KA6
SEC22A
SEC23B
SENP2
SFTPC
SLN
SMCO4
TCEA2
TMEM115
TMEM140
TMEM147
TMEM182
TMEM248
TMPRSS4
TRIM69
TSPAN15
VTI1B
ZNF250
ZNF648
69 interacting genes:
ADAP1
ASCC2
AURKA
BAG6
CBY2
CCNB1
CDK1
CDK11A
CDKN1A
CENPB
CHD3
CLEC3B
CNOT9
DCTN2
DNAJC13
EEF1A1
EEF1G
ERG28
FAM83D
FAS
FBN3
FTL
GADD45GIP1
GAPDH
GBP2
GNB2
H1-1
H2AC16
H2BC21
H3-4
H4-16
IGHM
IGSF21
JMJD1C
KHSRP
LMO4
LNX2
MAP3K4
MAPK14
MASP1
MDM2
MICAL1
MIDN
MPP1
NPM1
NRBP1
NUCB2
PARVG
PCNA
PFKFB4
PPARA
PSMC3
PTN
PTPRK
QARS1
RAI1
RBPJ
RPS2
RXRA
SH3GLB1
SPTBN4
SYNE4
TLE1
TP53
UBE2D1
UBR1
VIM
ZHX1
ZNF135
Entrez ID
163183
1647
HPRD ID
08776
00528
Ensembl ID
ENSG00000181392
ENSG00000116717
Uniprot IDs
Q8N205
A5JUZ3
P24522
PDB IDs
6R16
2KG4
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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