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CHUK and TGFBR1
Data Source:
HPRD
(in vivo)
CHUK
TGFBR1
Description
component of inhibitor of nuclear factor kappa B kinase complex
transforming growth factor beta receptor 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Nucleus
Endosome
Plasma Membrane
Bicellular Tight Junction
Cell Surface
Receptor Complex
Membrane Raft
Activin Receptor Complex
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Protein Homodimerization Activity
Protein-containing Complex Binding
Protein Heterodimerization Activity
Scaffold Protein Binding
Transferrin Receptor Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Type II Transforming Growth Factor Beta Receptor Binding
Protein Binding
ATP Binding
Activin Receptor Activity, Type I
Growth Factor Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
I-SMAD Binding
Biological Process
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-independent Toll-like Receptor Signaling Pathway
Skeletal Muscle Contraction
Protein Phosphorylation
Inflammatory Response
Immune Response
I-kappaB Kinase/NF-kappaB Signaling
I-kappaB Phosphorylation
Rho Protein Signal Transduction
Response To Virus
Response To Toxic Substance
Anatomical Structure Morphogenesis
Response To Acetate
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-serine Phosphorylation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Lipopolysaccharide
Positive Regulation Of Interferon-alpha Production
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Reactive Oxygen Species
TRIF-dependent Toll-like Receptor Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Response To Drug
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Amino Acid
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Striated Muscle Cell Differentiation
Stress-activated MAPK Cascade
Response To Cholecystokinin
Interleukin-1-mediated Signaling Pathway
Cellular Response To Cadmium Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Virus
Activation Of MAPKK Activity
Skeletal System Development
In Utero Embryonic Development
Kidney Development
Blastocyst Development
Epithelial To Mesenchymal Transition
Negative Regulation Of Endothelial Cell Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Lens Development In Camera-type Eye
Ventricular Trabecula Myocardium Morphogenesis
Ventricular Compact Myocardium Morphogenesis
Proepicardium Development
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Apoptotic Process
Cell Cycle Arrest
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Nervous System Development
Heart Development
Positive Regulation Of Cell Population Proliferation
Germ Cell Migration
Male Gonad Development
Post-embryonic Development
Anterior/posterior Pattern Specification
Positive Regulation Of Gene Expression
Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Protein Deubiquitination
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Collagen Fibril Organization
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Chondrocyte Differentiation
Activin Receptor Signaling Pathway
Intracellular Signal Transduction
Wound Healing
Endothelial Cell Activation
Extracellular Structure Organization
Regulation Of Protein Binding
Endothelial Cell Migration
Positive Regulation Of Transcription, DNA-templated
Thymus Development
Neuron Fate Commitment
Embryonic Cranial Skeleton Morphogenesis
Skeletal System Morphogenesis
Mesenchymal Cell Differentiation
Artery Morphogenesis
Cell Motility
Positive Regulation Of Cellular Component Movement
Positive Regulation Of Filopodium Assembly
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Protein Kinase B Signaling
Parathyroid Gland Development
Roof Of Mouth Development
Pharyngeal System Development
Regulation Of Cardiac Muscle Cell Proliferation
Cardiac Epithelial To Mesenchymal Transition
Pathway-restricted SMAD Protein Phosphorylation
Positive Regulation Of SMAD Protein Signal Transduction
Ventricular Septum Morphogenesis
Angiogenesis Involved In Coronary Vascular Morphogenesis
Coronary Artery Morphogenesis
Response To Cholesterol
Cellular Response To Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Positive Regulation Of Tight Junction Disassembly
Epicardium Morphogenesis
Positive Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
AKT phosphorylates targets in the cytosol
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Constitutive Signaling by AKT1 E17K in Cancer
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling activates SMADs
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
TGFBR1 KD Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
UCH proteinases
Ub-specific processing proteases
Drugs
Aminosalicylic acid
Mesalazine
Sulfasalazine
Acetylcysteine
4-(3-Pyridin-2-Yl-1h-Pyrazol-4-Yl)Quinoline
Naphthyridine Inhibitor
3-(4-Fluorophenyl)-2-(6-Methylpyridin-2-Yl)-5,6-Dihydro-4h-Pyrrolo[1,2-B]Pyrazole
N-[4-(5-fluoro-6-methylpyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-yl]acetamide
2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine
N-1H-indazol-5-yl-2-(6-methylpyridin-2-yl)quinazolin-4-amine
Fostamatinib
Diseases
Cocoon syndrome
Loeys-Dietz syndrome (LDS)
Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS
Liver enzyme levels (
18940312
)
Psoriasis (
28537254
)
Type 2 diabetes (
30054458
)
Advanced age-related macular degeneration (
26691988
)
Age-related macular degeneration (
23455636
)
Asthma (
31959851
32296059
)
Callous-unemotional behaviour (
23874384
)
Cough in response to angiotensin-converting enzyme inhibitor drugs (
28084903
)
Dental caries (
23064961
)
Epithelial ovarian cancer (
25134534
)
Fractures (paediatric) (
32742401
)
Gestational age at birth (maternal effect) (
28877031
)
Refractive error (
32231278
)
Spherical equivalent or myopia (age of diagnosis) (
29808027
)
Interacting Genes
81 interacting genes:
AKT1
AKT2
AMBRA1
ATR
BCL10
BCL3
BTRC
CASP8
CDC37
CHEK1
COPS5
CREBBP
CSF2RA
CSNK2A1
CTNNB1
CUEDC2
CUL1
DCUN1D5
E2F4
EIF2AK2
ELP1
ERBIN
ESR1
FKBP5
FOXO3
H3-4
H3C14
HSP90AA1
HSP90AB1
HTT
IFIT5
IKBKB
IKBKE
IKBKG
IRS1
MAP3K1
MAP3K11
MAP3K14
MAP3K4
MAP3K7
MAP3K8
NCOA3
NCOR1
NCOR2
NFKB1
NFKB2
NFKBIA
NFKBIB
NLRP4
NOTCH3
NR2C2
PAX8
PEBP1
PIAS1
PRKCB
PRKCI
PRKCQ
PRKDC
PTPN11
RELA
RICTOR
RIPK2
RPL27
SRC
SRPK1
SRPK2
STAP2
TANK
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TRAF2
TRAF3IP2
TRAF4
TRIM27
TRPC4AP
UBC
UBE2E3
UBE2I
UBE2N
163 interacting genes:
ACVR1
ACVRL1
AMHR2
ANAPC5
AP2B1
ARHGAP15
ARHGAP31
ARHGEF6
ARL4D
ARL8B
ASH2L
AURKB
BAMBI
BMPR1B
BMPR2
BTBD2
CAV1
CD44
CDC20
CDC42EP4
CDK14
CDK17
CDK4
CDK6
CDKL1
CHN1
CHN2
CHUK
CLU
CSNK1A1
CSNK2A2
CTNNB1
CUL5
DAB2
DAPK2
DCAF12
DCAF6
DUSP13
EIF2AK4
ENC1
ENG
FANCL
FBXL12
FBXO34
FKBP1A
FKBP1B
FNTA
GNA13
GNB2
GNB3
IKBKB
ITK
KATNB1
KCNK18
KLHL1
KLHL35
LIMS1
MAP3K20
MAP3K7
MYO3A
MYOC
MYT1L
NAT8
NEK6
NEK8
NKIRAS1
NRP1
NUAK2
NUP37
OSR1
OTUB1
OXSR1
PAK1
PARD6A
PIK3R1
PIK3R2
PLEK
PLEKHB1
PLEKHJ1
PLK4
PML
POMK
PPP2R2A
PPP3CC
PPP6C
PREB
PREX2
PRPF4
PSMD14
RAB13
RAB25
RAB33B
RAB34
RAB38
RAB3B
RAB6B
RAN
RAP2A
RASD2
RASL12
RGS19
RHEBL1
RHOA
RHOD
RHOG
RHOH
RHOJ
RHPN2
RNF130
RNF146
RNF5
RPAP3
RPS27A
RRH
RTKN
SAMD8
SAT2
SKAP2
SKI
SMAD1
SMAD2
SMAD3
SMAD4
SMAD6
SMAD7
SMURF2
SNTG1
SNX6
SOCS6
SQSTM1
STK35
STRAP
STUB1
STX8
STYXL1
TGFB1
TGFB2
TGFB3
TGFBR2
TGFBRAP1
TNNT1
TRAF6
TRAP1
TSC22D1
TSSK1B
TSSK4
TTC1
TTC27
TTPAL
UBA52
UBB
UBD
UBE2E3
UBE2Z
UBXN1
USP2
USP45
VEPH1
WDR13
WDR33
WDR61
XIAP
ZFYVE9
Entrez ID
1147
7046
HPRD ID
02811
01822
Ensembl ID
ENSG00000213341
ENSG00000106799
Uniprot IDs
O15111
B4DXN7
B4DY26
P36897
Q5T7S2
PDB IDs
3BRT
5EBZ
5TQW
5TQX
5TQY
1B6C
1IAS
1PY5
1RW8
1TBI
1VJY
2L5S
2PJY
2WOT
2WOU
2X7O
3FAA
3GXL
3HMM
3KCF
3KFD
3TZM
4X0M
4X2F
4X2G
4X2J
4X2K
4X2N
5E8S
5E8T
5E8U
5E8W
5E8X
5E8Z
5E90
5FRI
5QIK
5QIL
5QIM
5QTZ
5QU0
5USQ
6B8Y
6MAC
Enriched GO Terms of Interacting Partners
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