CLCN1 and FAM9B

Data Source:
BioGRID (two hybrid)

		CLCN1	FAM9B
Description		chloride voltage-gated channel 1	family with sequence similarity 9 member B
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Chloride Channel Complex Sarcolemma	Synaptonemal Complex Nucleoplasm
	Molecular Function	Voltage-gated Chloride Channel Activity Protein Binding Protein Homodimerization Activity	Protein Binding
	Biological Process	Chloride Transport Muscle Contraction Neuronal Action Potential Propagation Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Chloride Transmembrane Transport	Spermatid Development Meiotic Cell Cycle
Pathways		Stimuli-sensing channels
Drugs
Diseases		Myotonia congenita, including: Autosomal dominant myotonia congenita (Thomsen disease); Autosomal recessive myotonia congenita (Becker disease); Fluctuating myotonia congenita; Myotonia levoir
GWAS			Age at voice drop ( 27182965) Androgen levels ( 22936694) Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 29403010) Hemoglobin ( 29403010) Male-pattern baldness ( 29146897 27182965) Metabolite levels ( 23823483)
Interacting Genes		7 interacting genes: AHSA1 APPBP2 CIDEB FAM9B FKBP8 PRDM5 STIP1	142 interacting genes: ABT1 ACP6 ANKRD36B AP1M1 ASB6 ATF7 AURKAIP1 BAG6 BAIAP2L2 BARD1 BCL2A1 BET1 BLOC1S2 BRME1 BYSL C16orf72 C8orf33 CADPS CCDC106 CCDC116 CCDC198 CCDC70 CDC23 CDC37 CDC42EP4 CDCA7L CDSN CENPL CEP57L1 CEP95 CHRAC1 CLCN1 CMTM6 COL20A1 CSDE1 CWF19L2 DAPK2 DAXX DENND2D DGUOK DNAJC15 DNAJC4 EBNA1BP2 ECH1 EIF3G ELOA FAM161A FAM9A FASTKD3 FCHSD2 FERD3L FNDC11 GFOD1 GOPC GPX1 GRAMD4 GSTK1 HNRNPLL IBSP ISCU JAZF1 LBX1 LIN7A LINC02363 LMNA LNX1 LYRM2 MAB21L3 MFAP1 MOB1A MORF4L1 MORF4L2 MRPL10 MRPL28 MRPL9 MRRF MYG1 MYO15B NDE1 NDUFB10 NEBL NOL4 NOTO PAGE1 PAGE3 PHYH PIN4 POLL PPARA PPP1R18 PRPF3 PSMD14 PTRH1 RAB17 RAD51B RBM17 RBM23 RMND1 RNF8 RPL9 RSL24D1 RUBCN RUSC1 SDCBP SDCBP2 SERPINE2 SFN SLC16A3 SLPI SMARCB1 SMN1 SMN2 SNAP29 SNAP47 SNX20 SRRM4 STK3 SUCLA2 SURF6 SYT17 TBC1D25 TBRG4 TCEA2 TCEANC TGFBI TOM1L2 TRMT61B TSG101 TUFM TXN2 UBE2E2 URB1-AS1 WT1 XRCC4 YARS2 ZCCHC10 ZGPAT ZNF41 ZNF410 ZNF567 ZNF614 ZNF777
Entrez ID		1180	171483
HPRD ID		00320	15955
Ensembl ID		ENSG00000188037	ENSG00000177138
Uniprot IDs		P35523	A0A024RBV3 Q8IZU0
PDB IDs		6COY 6COZ 6QV6 6QVB 6QVC 6QVD 6QVU
Enriched GO Terms of Interacting Partners?
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