FAM9B and JAZF1

Data Source:
BioGRID (two hybrid)

		FAM9B	JAZF1
Description		family with sequence similarity 9 member B	JAZF zinc finger 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Synaptonemal Complex Nucleoplasm	Fibrillar Center Nucleus Nucleoplasm Cytosol Transcription Repressor Complex
	Molecular Function	Protein Binding	Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Spermatid Development Meiotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process
Pathways
Drugs
Diseases			Type II diabetes mellitus
GWAS		Age at voice drop ( 27182965) Androgen levels ( 22936694) Creatinine levels ( 29403010) Glomerular filtration rate ( 29403010) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 29403010) Hemoglobin ( 29403010) Male-pattern baldness ( 29146897 27182965) Metabolite levels ( 23823483)	Alanine transaminase levels ( 29403010) Alcoholic chronic pancreatitis ( 28754779) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Blond vs. brown/black hair color ( 30531825) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer, ovarian cancer or prostate cancer (pleiotropy) ( 27432226) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 23128233) Eosinophilic esophagitis ( 29904099) FEV1 ( 30804560) Free thyroxine concentration ( 24722205) Gout ( 22179738) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 19343178 23563607 18952825) Hip circumference adjusted for BMI ( 25673412) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Medication use (drugs used in diabetes) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Moyamoya disease ( 29273593) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of white cells ( 32888494) Peak expiratory flow ( 30804560) Prostate cancer ( 18264096 31562322) Prostate-specific antigen levels ( 28139693) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 26606652 26502338 28714469 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systolic blood pressure ( 30224653 30578418) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Total body bone mineral density ( 29304378) Triglyceride levels ( 32203549) Type 2 diabetes ( 27189021 22885922 18372903 24509480 30054458 26961502 29358691 30297969 31118516 32499647 20581827 28869590) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412 28448500) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		142 interacting genes: ABT1 ACP6 ANKRD36B AP1M1 ASB6 ATF7 AURKAIP1 BAG6 BAIAP2L2 BARD1 BCL2A1 BET1 BLOC1S2 BRME1 BYSL C16orf72 C8orf33 CADPS CCDC106 CCDC116 CCDC198 CCDC70 CDC23 CDC37 CDC42EP4 CDCA7L CDSN CENPL CEP57L1 CEP95 CHRAC1 CLCN1 CMTM6 COL20A1 CSDE1 CWF19L2 DAPK2 DAXX DENND2D DGUOK DNAJC15 DNAJC4 EBNA1BP2 ECH1 EIF3G ELOA FAM161A FAM9A FASTKD3 FCHSD2 FERD3L FNDC11 GFOD1 GOPC GPX1 GRAMD4 GSTK1 HNRNPLL IBSP ISCU JAZF1 LBX1 LIN7A LINC02363 LMNA LNX1 LYRM2 MAB21L3 MFAP1 MOB1A MORF4L1 MORF4L2 MRPL10 MRPL28 MRPL9 MRRF MYG1 MYO15B NDE1 NDUFB10 NEBL NOL4 NOTO PAGE1 PAGE3 PHYH PIN4 POLL PPARA PPP1R18 PRPF3 PSMD14 PTRH1 RAB17 RAD51B RBM17 RBM23 RMND1 RNF8 RPL9 RSL24D1 RUBCN RUSC1 SDCBP SDCBP2 SERPINE2 SFN SLC16A3 SLPI SMARCB1 SMN1 SMN2 SNAP29 SNAP47 SNX20 SRRM4 STK3 SUCLA2 SURF6 SYT17 TBC1D25 TBRG4 TCEA2 TCEANC TGFBI TOM1L2 TRMT61B TSG101 TUFM TXN2 UBE2E2 URB1-AS1 WT1 XRCC4 YARS2 ZCCHC10 ZGPAT ZNF41 ZNF410 ZNF567 ZNF614 ZNF777	4 interacting genes: FAM9B NR2C2 PPARG RXRA
Entrez ID		171483	221895
HPRD ID		15955	09373
Ensembl ID		ENSG00000177138	ENSG00000153814
Uniprot IDs		A0A024RBV3 Q8IZU0	Q86VZ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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