CLCN1 and PRDM5

Data Source:
BioGRID (two hybrid)

		CLCN1	PRDM5
Description		chloride voltage-gated channel 1	PR/SET domain 5
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Chloride Channel Complex Sarcolemma	Nucleus Nucleoplasm Nucleolus Nuclear Body
	Molecular Function	Voltage-gated Chloride Channel Activity Protein Binding Protein Homodimerization Activity	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Methyltransferase Activity Sequence-specific DNA Binding Metal Ion Binding Repressing Transcription Factor Binding
	Biological Process	Chloride Transport Muscle Contraction Neuronal Action Potential Propagation Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Chloride Transmembrane Transport	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Regulation Of Gene Expression Histone Deacetylation Negative Regulation Of Transcription, DNA-templated Histone H3-K9 Methylation Cellular Response To Leukemia Inhibitory Factor
Pathways		Stimuli-sensing channels
Drugs
Diseases		Myotonia congenita, including: Autosomal dominant myotonia congenita (Thomsen disease); Autosomal recessive myotonia congenita (Becker disease); Fluctuating myotonia congenita; Myotonia levoir
GWAS			F-cell distribution in sickle cell anaemia ( 21326311) Fasting plasma glucose ( 17903298) Loneliness (multivariate analysis) ( 27629369) Monobrow thickness ( 26926045) Obesity-related traits ( 23251661) Sensorimotor dexterity ( 31596458)
Interacting Genes		7 interacting genes: AHSA1 APPBP2 CIDEB FAM9B FKBP8 PRDM5 STIP1	7 interacting genes: ADPRS CLCN1 FAAP20 FBXO44 RASD1 TYK2 VIPR1
Entrez ID		1180	11107
HPRD ID		00320	17902
Ensembl ID		ENSG00000188037	ENSG00000138738
Uniprot IDs		P35523	Q9NQX1
PDB IDs		6COY 6COZ 6QV6 6QVB 6QVC 6QVD 6QVU
Enriched GO Terms of Interacting Partners?
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