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SNF8 and DVL2
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
SNF8
DVL2
Description
SNF8 subunit of ESCRT-II
dishevelled segment polarity protein 2
Image
GO Annotations
Cellular Component
ESCRT II Complex
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Late Endosome Membrane
Perinuclear Region Of Cytoplasm
Recycling Endosome
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Aggresome
Lateral Plasma Membrane
Nuclear Body
Cytoplasmic Vesicle
Apical Part Of Cell
Clathrin-coated Endocytic Vesicle
Molecular Function
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Channel Regulator Activity
Protein Homodimerization Activity
Protein N-terminus Binding
Frizzled Binding
Protein Binding
Protein Kinase Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Identical Protein Binding
Protein Self-association
Biological Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Gene Expression
Regulation Of Multivesicular Body Size Involved In Endosome Transport
Endosomal Transport
Macroautophagy
Endocytic Recycling
Multivesicular Body Assembly
Regulation Of Protein Catabolic Process
Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Regulation Of MAP Kinase Activity
Early Endosome To Late Endosome Transport
Positive Regulation Of Protein Catabolic Process
Regulation Of Protein Complex Stability
Multivesicular Body Sorting Pathway
Positive Regulation Of Exosomal Secretion
Regulation Of Viral Budding Via Host ESCRT Complex
Neural Tube Closure
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Regulation Of Transcription, DNA-templated
Segment Specification
Heart Development
Convergent Extension Involved In Neural Plate Elongation
Cellular Protein Localization
Hippo Signaling
Non-canonical Wnt Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of GTPase Activity
Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Neuron Projection Arborization
Beta-catenin Destruction Complex Disassembly
Pathways
Endosomal Sorting Complex Required For Transport (ESCRT)
HCMV Late Events
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
Signaling by Hippo
PCP/CE pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD4
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS
Coronary heart disease (
21378990
)
Type 2 diabetes (
29358691
)
Metabolite levels (
31628463
)
Metabolite levels (small molecules and protein measures) (
27005778
)
Interacting Genes
24 interacting genes:
ADORA1
AKAP9
CHMP6
CLP1
CT55
DVL2
ELL
FANCL
GLYCTK
GOLGA2
KDM1A
NIF3L1
PRMT6
RILP
SMARCD1
SUOX
SUV39H2
TRIM54
TSG101
TXLNA
VAC14
VPS25
VPS36
YWHAE
103 interacting genes:
ABL1
AKAP9
AP1M1
AP2M1
ARHGEF39
ARR3
ARRB1
ARRB2
ATN1
AXIN1
BAG3
BAHD1
BCL6
BEND7
BYSL
CARD9
CCDC33
CPSF7
CSNK1E
CTBP2
DAAM1
DCUN1D1
DDI1
DPPA2
DYNLT1
EIF1B
ELOA2
ENKD1
FAM161A
FAM90A1
FZD4
GABARAP
GABARAPL1
GMCL2
GOLGA2
GRAP2
GRB2
HIP1
IHO1
KLHL12
LMO3
LRRK2
MAGOHB
MAP1LC3A
MCRS1
NOL12
NUP62CL
OTULIN
PARD6A
PCBD1
PLA2G12A
POLI
PPM1A
PPP1R16B
PRKAA1
PRKCA
PRKCB
PRKCG
PRPF3
PRPF31
PSMF1
RAC1
RBFOX1
RBPMS
RHOA
RHOXF2
RNF185
RNPS1
RUNX2
RUSC1
SCNM1
SMURF1
SNF8
SNIP1
SORBS3
SSX2IP
TAB1
TDP2
THAP1
TIFA
TLE5
TP53
TPM3
TRAF2
U2AF2
UBAC1
UBE2D3
UIMC1
USP5
USP9X
VANGL1
VHL
WAS
WT1
YES1
ZBTB48
ZBTB8A
ZGPAT
ZNF165
ZNF250
ZNF263
ZNF410
ZNF581
Entrez ID
11267
1856
HPRD ID
16847
03690
Ensembl ID
ENSG00000159210
ENSG00000004975
Uniprot IDs
Q96H20
O14641
PDB IDs
2ZME
3CUQ
2REY
3CBX
3CBY
3CBZ
3CC0
4WIP
5LNP
5SUY
5SUZ
6IW3
6JCK
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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