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DVL2 and ENKD1
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
DVL2
ENKD1
Description
dishevelled segment polarity protein 2
enkurin domain containing 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Aggresome
Lateral Plasma Membrane
Nuclear Body
Cytoplasmic Vesicle
Apical Part Of Cell
Clathrin-coated Endocytic Vesicle
Cytoplasmic Microtubule
Microtubule Cytoskeleton
Ciliary Base
Molecular Function
Frizzled Binding
Protein Binding
Protein Kinase Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Identical Protein Binding
Protein Self-association
Protein Binding
Biological Process
Neural Tube Closure
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Regulation Of Transcription, DNA-templated
Segment Specification
Heart Development
Convergent Extension Involved In Neural Plate Elongation
Cellular Protein Localization
Hippo Signaling
Non-canonical Wnt Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of GTPase Activity
Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Neuron Projection Arborization
Beta-catenin Destruction Complex Disassembly
Pathways
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
Signaling by Hippo
PCP/CE pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD4
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS
Metabolite levels (
31628463
)
Metabolite levels (small molecules and protein measures) (
27005778
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
103 interacting genes:
ABL1
AKAP9
AP1M1
AP2M1
ARHGEF39
ARR3
ARRB1
ARRB2
ATN1
AXIN1
BAG3
BAHD1
BCL6
BEND7
BYSL
CARD9
CCDC33
CPSF7
CSNK1E
CTBP2
DAAM1
DCUN1D1
DDI1
DPPA2
DYNLT1
EIF1B
ELOA2
ENKD1
FAM161A
FAM90A1
FZD4
GABARAP
GABARAPL1
GMCL2
GOLGA2
GRAP2
GRB2
HIP1
IHO1
KLHL12
LMO3
LRRK2
MAGOHB
MAP1LC3A
MCRS1
NOL12
NUP62CL
OTULIN
PARD6A
PCBD1
PLA2G12A
POLI
PPM1A
PPP1R16B
PRKAA1
PRKCA
PRKCB
PRKCG
PRPF3
PRPF31
PSMF1
RAC1
RBFOX1
RBPMS
RHOA
RHOXF2
RNF185
RNPS1
RUNX2
RUSC1
SCNM1
SMURF1
SNF8
SNIP1
SORBS3
SSX2IP
TAB1
TDP2
THAP1
TIFA
TLE5
TP53
TPM3
TRAF2
U2AF2
UBAC1
UBE2D3
UIMC1
USP5
USP9X
VANGL1
VHL
WAS
WT1
YES1
ZBTB48
ZBTB8A
ZGPAT
ZNF165
ZNF250
ZNF263
ZNF410
ZNF581
207 interacting genes:
ABI1
ABI2
ACOT7
AKAP8L
ANKRD23
ANKRD49
APP
ARMC5
ASB3
AVPI1
BANP
BCAS2
BCAS4
BCAT1
BEGAIN
BEX3
BHLHB9
BLZF1
BRAT1
C18orf54
C19orf54
C1orf105
CALCOCO1
CALCOCO2
CBY1
CBY2
CCDC102B
CCDC13
CCDC136
CCDC28B
CCDC85B
CDCA4
CDPF1
CDR2
CDSN
CEP55
CEP70
CHCHD3
CHRDL2
COA7
CTBP2
CYSRT1
DGCR6
DVL2
DVL3
DYDC1
ECM1
EFHC2
EIF4G1
EYA2
EZHIP
FAM102A
FAM228A
FAM90A1
FCHSD2
FKBP6
FOS
FOSB
FSD2
GADD45G
GADD45GIP1
GET4
GFAP
GIGYF1
GOLGA2
GOLGA6A
GOLGA6L9
GRHL3
GRIPAP1
HMBOX1
HNRNPH1
HOMEZ
HOOK2
HOXA1
HSF2BP
HSPB2
HSPB2-C11orf52
ID2
IGF1
IGFBP6
IKBKG
IKZF3
JAKMIP1
KIFC3
KLHL20
KLHL26
KRT14
KRT15
KRT31
KRT35
KRT40
KRTAP10-5
KRTAP10-8
KRTAP11-1
KRTAP12-1
KRTAP13-2
KRTAP19-1
KRTAP19-5
KRTAP19-6
KRTAP4-11
KRTAP5-9
KRTAP6-2
LDOC1
LHX3
LIN7B
LMO2
LRRC61
LZTS1
MAPK9
MATN4
MDFI
MEIS3
MESD
METTL27
MID2
MIF4GD
MIPOL1
MISP
MKRN3
MLH1
MORN3
MORN5
MRNIP
MRPL28
MRPL38
MTUS2
MYF5
MYOZ3
N4BP3
NAB2
NBPF22P
NBPF6
NCKIPSD
NDUFB7
NEFL
NFKBIA
NHLRC4
NUTM1
OOEP
PAK5
PDLIM7
PDZD4
PHC2
PIBF1
PICK1
PIK3R3
PKNOX2
PLSCR1
PNMA1
PNMA2
POLR3C
PPP1CC
PPP2R3C
PRDM14
PRDM6
RAD54B
RBCK1
RBM11
RBPMS
RCN1
RUBCN
RUNDC3A
SLC15A2
SNRNP48
SORBS3
SPAG5
SPDEF
SPSB3
SRGAP3
SSC4D
STAC3
STXBP4
TENT5B
TNNI1
TNS2
TOX2
TRAF1
TRAF2
TRAK1
TRGV7
TRIM23
TRIM27
TRIM35
TRIM54
TSC1
TSC22D4
TSEN15
UBXN11
USH1C
USH1G
USHBP1
USP20
VBP1
VPS37B
VWC2
WDR62
WWOX
YWHAE
ZBTB14
ZC2HC1C
ZFP90
ZNF143
ZNF426
ZNF511
ZNF581
ZNF76
ZRANB1
Entrez ID
1856
84080
HPRD ID
03690
13151
Ensembl ID
ENSG00000004975
ENSG00000124074
Uniprot IDs
O14641
Q9H0I2
PDB IDs
2REY
3CBX
3CBY
3CBZ
3CC0
4WIP
5LNP
5SUY
5SUZ
6IW3
6JCK
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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