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DVL2 and UIMC1
Data Source:
BioGRID
(two hybrid)
DVL2
UIMC1
Description
dishevelled segment polarity protein 2
ubiquitin interaction motif containing 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Aggresome
Lateral Plasma Membrane
Nuclear Body
Cytoplasmic Vesicle
Apical Part Of Cell
Clathrin-coated Endocytic Vesicle
Nucleus
Nucleoplasm
Nuclear Body
BRCA1-A Complex
Molecular Function
Frizzled Binding
Protein Binding
Protein Kinase Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Small GTPase Binding
Identical Protein Binding
Protein Self-association
DNA Binding
Protein Binding
Histone Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Neural Tube Closure
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Regulation Of Transcription, DNA-templated
Segment Specification
Heart Development
Convergent Extension Involved In Neural Plate Elongation
Cellular Protein Localization
Hippo Signaling
Non-canonical Wnt Signaling Pathway
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of GTPase Activity
Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Canonical Wnt Signaling Pathway
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Membrane Organization
Positive Regulation Of Protein Tyrosine Kinase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Cochlea Morphogenesis
Planar Cell Polarity Pathway Involved In Neural Tube Closure
Positive Regulation Of Neuron Projection Arborization
Beta-catenin Destruction Complex Disassembly
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Response To Ionizing Radiation
Protein Deubiquitination
Positive Regulation Of DNA Repair
Negative Regulation Of Transcription, DNA-templated
Histone H2A K63-linked Deubiquitination
Signal Transduction Involved In G2 DNA Damage Checkpoint
Pathways
TCF dependent signaling in response to WNT
WNT mediated activation of DVL
Signaling by Hippo
PCP/CE pathway
PCP/CE pathway
Asymmetric localization of PCP proteins
Degradation of DVL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
WNT5A-dependent internalization of FZD4
Negative regulation of TCF-dependent signaling by DVL-interacting proteins
RHO GTPases Activate Formins
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
WNT5:FZD7-mediated leishmania damping
WNT5:FZD7-mediated leishmania damping
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
Metabolite levels (
31628463
)
Metabolite levels (small molecules and protein measures) (
27005778
)
Activated partial thromboplastin time (
22703881
)
Menarche and menopause (age at onset) (
19448621
)
Menopause (age at onset) (
22267201
26414677
29773799
)
Uterine fibroids (
31649266
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
103 interacting genes:
ABL1
AKAP9
AP1M1
AP2M1
ARHGEF39
ARR3
ARRB1
ARRB2
ATN1
AXIN1
BAG3
BAHD1
BCL6
BEND7
BYSL
CARD9
CCDC33
CPSF7
CSNK1E
CTBP2
DAAM1
DCUN1D1
DDI1
DPPA2
DYNLT1
EIF1B
ELOA2
ENKD1
FAM161A
FAM90A1
FZD4
GABARAP
GABARAPL1
GMCL2
GOLGA2
GRAP2
GRB2
HIP1
IHO1
KLHL12
LMO3
LRRK2
MAGOHB
MAP1LC3A
MCRS1
NOL12
NUP62CL
OTULIN
PARD6A
PCBD1
PLA2G12A
POLI
PPM1A
PPP1R16B
PRKAA1
PRKCA
PRKCB
PRKCG
PRPF3
PRPF31
PSMF1
RAC1
RBFOX1
RBPMS
RHOA
RHOXF2
RNF185
RNPS1
RUNX2
RUSC1
SCNM1
SMURF1
SNF8
SNIP1
SORBS3
SSX2IP
TAB1
TDP2
THAP1
TIFA
TLE5
TP53
TPM3
TRAF2
U2AF2
UBAC1
UBE2D3
UIMC1
USP5
USP9X
VANGL1
VHL
WAS
WT1
YES1
ZBTB48
ZBTB8A
ZGPAT
ZNF165
ZNF250
ZNF263
ZNF410
ZNF581
22 interacting genes:
ABRAXAS1
ATP8A2
BRCC3
CEP57
CREBBP
DVL2
ECPAS
ESR1
FANCG
H2AC20
INO80B
MDC1
NR6A1
RAD23A
SKIL
SUMO2
TP53
UBB
UBC
USP13
WBP2
ZMYM3
Entrez ID
1856
51720
HPRD ID
03690
11482
Ensembl ID
ENSG00000004975
ENSG00000087206
Uniprot IDs
O14641
A0A024R7R0
Q96RL1
PDB IDs
2REY
3CBX
3CBY
3CBZ
3CC0
4WIP
5LNP
5SUY
5SUZ
6IW3
6JCK
2MKF
2MKG
2N9E
2RR9
Enriched GO Terms of Interacting Partners
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