WBP4 and SNW1

Data Source:
BioGRID (two hybrid)

		WBP4	SNW1
Description		WW domain binding protein 4	SNW domain containing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Matrix Nuclear Body Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Proline-rich Region Binding	Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Notch Binding Protein Binding Enzyme Binding Nuclear Hormone Receptor Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding SMAD Binding Androgen Receptor Binding
	Biological Process	MRNA Splicing, Via Spliceosome RNA Splicing MRNA Cis Splicing, Via Spliceosome	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Viral Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation By Host Of Viral Transcription Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Neurogenesis Positive Regulation Of Histone H3-K4 Methylation Regulation Of Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Retinoic Acid
Pathways		mRNA Splicing - Major Pathway	Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway mRNA Splicing - Major Pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS		Crohn's disease ( 23266558) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Intraocular pressure ( 29617998) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269)	Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)
Interacting Genes		54 interacting genes: ARGLU1 BUB3 CAPRIN1 CHERP CHTF8 CPSF6 CPSF7 DDX23 DDX3X DHX15 DHX38 DIAPH1 DNM2 EFTUD2 EWSR1 FAM50B FUS HLTF HNRNPK HNRNPU HTATSF1 ISY1 KHDRBS1 NONO PABPC1 PPIA PRPF3 PRPF4 PRPF40A PSPC1 SART1 SCAF4 SF1 SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SNRNP200 SNRNP70 SNRPA SNRPB SNW1 TCERG1 TIA1 WAS WBP11 WDR83 WIPF1 XRCC6 ZC2HC1A ZNF207	97 interacting genes: ABLIM3 ACTN2 ASCC2 BICD2 BYSL C1orf216 CCDC125 CEP55 CEP70 CIR1 CWF19L2 DAXX EP300 ERCC3 EXOSC5 FAM90A1 GABPB1 GAS2L2 GOLGA2 GRIPAP1 HDAC2 HMBOX1 HOOK2 HSF2BP IKBKG IKZF1 JDP2 KANK2 KRT40 LRP2BP LZTS2 MAGEA1 MAGOHB MAPK6 MCMBP MEN1 MFAP1 MISP MSL1 MTUS2 NCK2 NCOA1 NCOR1 NCOR2 NOTCH1 NOTCH3 NR0B1 NR0B2 NXF1 OCLN ODF2 OSTF1 PABPN1 PCBD2 PGR PICK1 PPIL1 PRKAA2 PRKAR1B RABEP1 RARA RB1 RBL1 RBL2 RBPJ RINT1 RXRA SAAL1 SART1 SIN3A SIRT1 SKI SMAD2 SMAD3 SMAD4 SNRNP200 SNU13 SPECC1L STEEP1 SUMO2 TCP11L1 TEX11 TFIP11 TNNT1 TOP1 TRAF1 TRIM15 TRIM23 TRIM55 TRIM63 TTC14 USF1 VAV2 VDR VPS39 WBP4 ZSCAN1
Entrez ID		11193	22938
HPRD ID		16086	04340
Ensembl ID		ENSG00000120688	ENSG00000100603
Uniprot IDs		O75554	G3V3A4 Q13573
PDB IDs		2DK1 2JXW 5O9Z 6AHD	5MQF 5XJC 5YZG 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P
Enriched GO Terms of Interacting Partners?
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