CHD3 and MYB

Data Source:
BioGRID (pull down)

		CHD3	MYB
Description		chromodomain helicase DNA binding protein 3	MYB proto-oncogene, transcription factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome NuRD Complex PML Body Centriolar Satellite	Nucleus Nucleoplasm Cytosol Nuclear Matrix
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA Helicase Activity RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding ATPase Activity Double-stranded DNA Helicase Activity Nucleosome-dependent ATPase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Assembly Or Disassembly Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spindle Organization Centrosome Cycle DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Response To Hypoxia Chromatin Remodeling Regulation Of Transcription, DNA-templated Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of T-helper Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K9 Methylation Positive Regulation Of Glial Cell Proliferation Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Hepatic Stellate Cell Proliferation Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of Testosterone Secretion
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS	RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Ischemic stroke ( 26089329) Macular thickness ( 30535121) Prostate cancer ( 29892016) Refractive error ( 32231278) Stroke ( 26089329)	Aspartate aminotransferase levels ( 29403010) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Beta thalassemia/hemoglobin E disease ( 20183929) Eosinophil counts ( 29403010) Eosinophil percentage of white cells ( 32888494) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736 28898252) HbA2 levels ( 23043469) Hematocrit ( 29403010 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 26366553) Hodgkin's lymphoma ( 24149102) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 23263863 29403010 19853236 28453575 20139978 28548082 19862010 28031487) Mean corpuscular hemoglobin concentration ( 23263863 29403010 20139978) Mean corpuscular volume ( 23263863 29403010 19853236 28453575 20139978 19862010 28031487) Mean platelet volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 21833088) Myeloproliferative neoplasms ( 25849990) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Other erythrocyte phenotypes ( 19862010) Platelet count ( 26805783 22139419 24026423 29066854 29403010 19853236 22423221 20139978 28031487) Red blood cell count ( 29403010 28453575 20139978 28031487) Red blood cell traits ( 20927387 23935956) White blood cell count ( 29403010 32888494 20139978) White blood cell count (basophil) ( 27863252) White blood cell types ( 21738478)
Interacting Genes		96 interacting genes: ACTR1B ADH5 AIMP2 ATP5IF1 BARD1 BCL6 BHLHE40 C4orf17 CASP6 CASP8 CPE CRCT1 CREB1 CREBBP CSTF2 CTBP1 CTTN ENTR1 FABP4 FBP2 FUBP1 GADD45A GIT1 GPS2 GSK3B H3C1 HABP4 HSD17B10 HSPH1 HTT IK IKZF1 IKZF3 IMMT IVNS1ABP KIF15 KPNA2 KPNB1 LRIF1 LUC7L2 MAFG MAN2A2 MX1 MYB NEFL NR1H2 NR4A1 PAICS PCMT1 PIAS4 PLK4 PRG2 PRPF40A PSME1 PTN PTPRS PUF60 RAD51 RETREG2 RGS2 RIF1 RPL29 SAFB SAT1 SATB1 SERBP1 SERF2 SGSM2 SIRT6 SKIL SLC27A6 SPOP SRRT SUMO1 SUMO2 TAL1 TCERG1 THOC7 TNFRSF14 TNNT1 TP53 TP73 TRIM28 TRIM54 TSC22D1 TSPAN6 TTR TXNDC9 UBA3 UBC UBE2I UROD VIM XRCC4 YAE1 ZHX1	49 interacting genes: BTRC CCND3 CEBPB CEBPE CHD3 CNOT9 CREBBP CSNK2A1 EP300 ERC2 FBXW2 FBXW5 FBXW7 H2AC4 H2BC3 H3-4 H3C1 H4C1 HIPK2 HLF KAT2A MAF MAPK1 MYBBP1A MYOZ2 NCL NCOR1 NLK PAIP1 PAX5 PIAS1 PML PPM1K RBX1 RPL4 SIN3A SKI SKP2 SMARCA2 SND1 SP100 SUMO1 SUMO2 TRIM28 TTF2 UBE2I UPF2 ZFHX3 ZMYND11
Entrez ID		1107	4602
HPRD ID		09071	01810
Ensembl ID		ENSG00000170004	ENSG00000118513
Uniprot IDs		B3KWV4 Q12873 Q2TAZ1	P10242 Q708E9
PDB IDs
Enriched GO Terms of Interacting Partners?
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