MYB and MAPK1

Data Source:
HPRD (in vitro, in vivo)

		MYB	MAPK1
Description		MYB proto-oncogene, transcription factor	mitogen-activated protein kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Matrix	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Early Endosome Late Endosome Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Caveola Focal Adhesion Postsynaptic Density Axon Pseudopodium Dendrite Cytoplasm Protein-containing Complex Azurophil Granule Lumen Perikaryon Mitotic Spindle Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding	Phosphotyrosine Residue Binding Double-stranded DNA Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Transcription Factor Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Phosphatase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Response To Hypoxia Chromatin Remodeling Regulation Of Transcription, DNA-templated Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of T-helper Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K9 Methylation Positive Regulation Of Glial Cell Proliferation Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Hepatic Stellate Cell Proliferation Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of Testosterone Secretion	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Apoptotic Process Chemotaxis Cellular Response To DNA Damage Stimulus Cell Cycle Signal Transduction Cell Surface Receptor Signaling Pathway Chemical Synaptic Transmission Axon Guidance Aging Learning Or Memory Fibroblast Growth Factor Receptor Signaling Pathway Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Phosphatidylinositol 3-kinase Signaling Diadenosine Tetraphosphate Biosynthetic Process Viral Process Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sensory Perception Of Pain Cytosine Metabolic Process Platelet Activation Regulation Of Ossification Regulation Of Cellular PH Thyroid Gland Development Regulation Of Protein Stability Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Stress-activated MAPK Cascade Mammary Gland Epithelial Cell Proliferation Cellular Response To Amino Acid Starvation Cellular Response To Reactive Oxygen Species Response To Nicotine Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ERBB Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Outer Ear Morphogenesis Neutrophil Degranulation Response To Exogenous DsRNA Response To Estrogen Negative Regulation Of Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated Decidualization Thymus Development T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Stress-activated MAPK Cascade Regulation Of Cytoskeleton Organization Positive Regulation Of Telomerase Activity Bergmann Glial Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Long-term Synaptic Potentiation Face Development Lung Morphogenesis Trachea Formation Labyrinthine Layer Blood Vessel Development Cardiac Neural Crest Cell Development Involved In Heart Development ERK1 And ERK2 Cascade Response To Epidermal Growth Factor Cellular Response To Cadmium Ion Cellular Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Macrophage Proliferation Regulation Of Cellular Response To Heat Cellular Response To Dopamine Positive Regulation Of Telomere Capping Regulation Of Early Endosome To Late Endosome Transport
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production	phospho-PLA2 pathway RAF-independent MAPK1/3 activation MAPK1 (ERK2) activation Spry regulation of FGF signaling Golgi Cisternae Pericentriolar Stack Reorganization Frs2-mediated activation ERK/MAPK targets ERK/MAPK targets ERKs are inactivated Regulation of actin dynamics for phagocytic cup formation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Oncogene Induced Senescence FCERI mediated MAPK activation Regulation of HSF1-mediated heat shock response NCAM signaling for neurite out-growth Recycling pathway of L1 RSK activation Signal transduction by L1 Activation of the AP-1 family of transcription factors Thrombin signalling through proteinase activated receptors (PARs) Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate NADPH Oxidases RAF/MAP kinase cascade MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signal attenuation Advanced glycosylation endproduct receptor signaling Gastrin-CREB signalling pathway via PKC and MAPK ESR-mediated signaling RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Regulation of the apoptosome activity Estrogen-stimulated signaling through PRKCZ Estrogen-dependent nuclear events downstream of ESR-membrane signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Suppression of apoptosis Signaling downstream of RAS mutants Signaling by MAP2K mutants Signaling by MAPK mutants Signaling by RAF1 mutants FCGR3A-mediated phagocytosis Growth hormone receptor signaling
Drugs			Acetylsalicylic acid Minocycline Isoprenaline Arsenic trioxide Olomoucine Phosphonothreonine Purvalanol SB220025 Seliciclib Perifosine N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE (3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID 4-[4-(4-Fluorophenyl)-2-[4-[(R)-methylsulfinyl]phenyl]-1H-imidazol-5-yl]pyridine Turpentine Ulixertinib
Diseases
GWAS		Aspartate aminotransferase levels ( 29403010) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Beta thalassemia/hemoglobin E disease ( 20183929) Eosinophil counts ( 29403010) Eosinophil percentage of white cells ( 32888494) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736 28898252) HbA2 levels ( 23043469) Hematocrit ( 29403010 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 26366553) Hodgkin's lymphoma ( 24149102) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 23263863 29403010 19853236 28453575 20139978 28548082 19862010 28031487) Mean corpuscular hemoglobin concentration ( 23263863 29403010 20139978) Mean corpuscular volume ( 23263863 29403010 19853236 28453575 20139978 19862010 28031487) Mean platelet volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 21833088) Myeloproliferative neoplasms ( 25849990) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Other erythrocyte phenotypes ( 19862010) Platelet count ( 26805783 22139419 24026423 29066854 29403010 19853236 22423221 20139978 28031487) Red blood cell count ( 29403010 28453575 20139978 28031487) Red blood cell traits ( 20927387 23935956) White blood cell count ( 29403010 32888494 20139978) White blood cell count (basophil) ( 27863252) White blood cell types ( 21738478)	Bipolar disorder ( 31043756) Body size at age 10 ( 32376654) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 31604244 24076602 21833088) Superior parietal cortex volume ( 31530798)
Interacting Genes		49 interacting genes: BTRC CCND3 CEBPB CEBPE CHD3 CNOT9 CREBBP CSNK2A1 EP300 ERC2 FBXW2 FBXW5 FBXW7 H2AC4 H2BC3 H3-4 H3C1 H4C1 HIPK2 HLF KAT2A MAF MAPK1 MYBBP1A MYOZ2 NCL NCOR1 NLK PAIP1 PAX5 PIAS1 PML PPM1K RBX1 RPL4 SIN3A SKI SKP2 SMARCA2 SND1 SP100 SUMO1 SUMO2 TRIM28 TTF2 UBE2I UPF2 ZFHX3 ZMYND11	248 interacting genes: AR ARRB1 ARRB2 ATF2 ATP1A1 BANP BCL2 BCL3 BCL6 BRAF C1QBP CACYBP CAD CALCOCO1 CAPN2 CASP8 CASP9 CAV1 CD19 CDC25C CDX2 CEBPB CEP55 CHN1 CITED2 CMTM3 COPS6 CREBBP CRP CSNK2A1 CTNND1 CTSD CUEDC2 DAPK1 DUSP1 DUSP16 DUSP2 DUSP3 DUSP4 DUSP5 DUSP6 DUSP7 DUSP9 DYRK1B EGFR EGLN3 EIF4EBP1 ELK1 ELK4 ENAH EP300 EPOR ERF ESR1 ESR2 ETS1 FCGR2B FHL3 FOS FOXO3 FRS2 FRS3 GAB1 GAB2 GABRR1 GAPDH GATA1 GATA2 GATA4 GJA1 GMFB GNPTAB GORASP2 GRB10 GRB2 GSK3B HDAC4 HDAC6 HIF1A HNF4A HOMEZ HSF1 HSF4 HSP90AA1 ID2 IER3 IFI35 IFNAR1 IQGAP1 IRS1 ITGB6 JUN JUND KARS1 KDR KHDRBS1 KLF11 KRT8 KSR1 KSR2 LAMTOR3 LCK LIFR LIPE LRPAP1 LRRC4 LZTS2 MAFA MAP2K1 MAP2K2 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K10 MAPK14 MAPK8 MAPKAPK5 MAPT MBP MCL1 MDFI METAP2 MITF MKNK1 MKNK2 MSX2 MTIF3 MTPN MYB MYC NCOA1 NCOA3 NDE1 NEFH NEK2 NGFR NKX2-1 NOXA1 NR3C1 NR4A1 NR4A2 NR5A1 NRL NTRK3 NUP153 PAK1 PAK2 PAX5 PDE4D PEA15 PEBP1 PKM PLA2G4A PLAGL2 PLAT PLCB1 PLK3 POLR2G PPARA PPARG PPP1CA PPP1R18 PPP1R9B PPP2CA PPP2R5B PPP2R5C PRDX6 PRKCD PRKCE PRKCZ PRPSAP1 PSMA1 PTPDC1 PTPN1 PTPN5 PTPN7 PTPRC PTPRE PTPRH PTPRR PXN RAF1 RB1 REST RET RGS19 RNF216 RNF8 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KB1 RPTOR RUNX1 RXRA SCNN1G SH2D3C SHANK3 SHC1 SLC9A1 SMAD1 SMAD2 SMAD3 SMAD4 SNCA SNCG SORBS3 SOS1 SP1 SREBF1 SREBF2 STAT3 STAT5A STAT5B STXBP1 STYX SUPT20H TCF3 TFCP2 TGIF1 TH TIAL1 TLE5 TNFRSF1A TNFRSF25 TNFSF11 TNIP1 TNIP2 TNKS2 TOB1 TOP2A TP53 TPR TSC2 TTN TXNIP UBE3A UBR5 UBTF VAV1 VDR YBX1 YBX3 ZBTB42 ZC3HC1 ZFP36
Entrez ID		4602	5594
HPRD ID		01810	01496
Ensembl ID		ENSG00000118513	ENSG00000100030
Uniprot IDs		P10242 Q708E9	P28482 Q1HBJ4 Q499G7
PDB IDs			1PME 1TVO 1WZY 2OJG 2OJI 2OJJ 2Y9Q 3D42 3D44 3I5Z 3I60 3SA0 3TEI 3W55 4FMQ 4FUX 4FUY 4FV0 4FV1 4FV2 4FV3 4FV4 4FV5 4FV6 4FV7 4FV8 4FV9 4G6N 4G6O 4H3P 4H3Q 4IZ5 4IZ7 4IZA 4N0S 4NIF 4O6E 4QP1 4QP2 4QP3 4QP4 4QP6 4QP7 4QP8 4QP9 4QPA 4QTA 4QTE 4XJ0 4ZXT 4ZZM 4ZZN 4ZZO 5AX3 5BUE 5BUI 5BUJ 5BVD 5BVE 5BVF 5K4I 5LCJ 5LCK 5NGU 5NHF 5NHH 5NHJ 5NHL 5NHO 5NHP 5NHV 5V60 5V61 5V62 5WP1 6D5Y 6DMG 6G54 6G8X 6G91 6G92 6G93 6G97 6G9A 6G9D 6G9H 6G9J 6G9K 6G9M 6G9N 6GDM 6GDQ 6GE0 6GJB 6GJD 6NBS 6OPG 6OPH 6OPI 6Q7K 6Q7S 6Q7T 6QA1 6QA3 6QA4 6QAG 6QAH 6QAL 6QAQ 6QAW 6RQ4 6SLG
Enriched GO Terms of Interacting Partners?
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