MYB and PPM1K

Data Source:
BioGRID (two hybrid)

		MYB	PPM1K
Description		MYB proto-oncogene, transcription factor	protein phosphatase, Mg2+/Mn2+ dependent 1K
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Matrix	Mitochondrion Mitochondrial Matrix
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding	Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Response To Hypoxia Chromatin Remodeling Regulation Of Transcription, DNA-templated Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of T-helper Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K9 Methylation Positive Regulation Of Glial Cell Proliferation Cellular Response To Hydrogen Peroxide Cellular Response To Retinoic Acid Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Hematopoietic Stem Cell Differentiation Positive Regulation Of Hepatic Stellate Cell Proliferation Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of Testosterone Secretion	Protein Dephosphorylation Branched-chain Amino Acid Catabolic Process
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis Factors involved in megakaryocyte development and platelet production	Branched-chain amino acid catabolism
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 29403010) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Beta thalassemia/hemoglobin E disease ( 20183929) Eosinophil counts ( 29403010) Eosinophil percentage of white cells ( 32888494) Fetal hemoglobin levels in sickle cell anemia ( 25372704) Glycated hemoglobin levels ( 24647736 28898252) HbA2 levels ( 23043469) Hematocrit ( 29403010 19862010) Hematological and biochemical traits ( 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010) Hemoglobin A1c levels ( 29403010) Hemoglobin levels ( 26366553) Hodgkin's lymphoma ( 24149102) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 23263863 29403010 19853236 28453575 20139978 28548082 19862010 28031487) Mean corpuscular hemoglobin concentration ( 23263863 29403010 20139978) Mean corpuscular volume ( 23263863 29403010 19853236 28453575 20139978 19862010 28031487) Mean platelet volume ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 21833088) Myeloproliferative neoplasms ( 25849990) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Other erythrocyte phenotypes ( 19862010) Platelet count ( 26805783 22139419 24026423 29066854 29403010 19853236 22423221 20139978 28031487) Red blood cell count ( 29403010 28453575 20139978 28031487) Red blood cell traits ( 20927387 23935956) White blood cell count ( 29403010 32888494 20139978) White blood cell count (basophil) ( 27863252) White blood cell types ( 21738478)	Blood metabolite levels ( 24816252) Branched-chain amino acid levels (Isoleucine) ( 27898682) Branched-chain amino acid levels (Leucine) ( 27898682) Branched-chain amino acid levels (Valine) ( 27898682) Coffee consumption (cups per day) ( 25288136) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Metabolite levels ( 22286219 22916037) Metabolite levels (small molecules and protein measures) ( 27005778) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Serum uric acid levels ( 32514006)
Interacting Genes		49 interacting genes: BTRC CCND3 CEBPB CEBPE CHD3 CNOT9 CREBBP CSNK2A1 EP300 ERC2 FBXW2 FBXW5 FBXW7 H2AC4 H2BC3 H3-4 H3C1 H4C1 HIPK2 HLF KAT2A MAF MAPK1 MYBBP1A MYOZ2 NCL NCOR1 NLK PAIP1 PAX5 PIAS1 PML PPM1K RBX1 RPL4 SIN3A SKI SKP2 SMARCA2 SND1 SP100 SUMO1 SUMO2 TRIM28 TTF2 UBE2I UPF2 ZFHX3 ZMYND11	14 interacting genes: AATK BIRC2 ERBB3 HSF2BP HSPB2 LMTK2 MAGEA11 MYB MYO15B NTAQ1 PTK7 UBXN11 XIAP ZNF410
Entrez ID		4602	152926
HPRD ID		01810	15167
Ensembl ID		ENSG00000118513	ENSG00000163644
Uniprot IDs		P10242 Q708E9	Q8N3J5
PDB IDs			2IQ1 4DA1 6AK7
Enriched GO Terms of Interacting Partners?
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