CHD3 and SRRT

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		CHD3	SRRT
Description		chromodomain helicase DNA binding protein 3	serrate, RNA effector molecule
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome NuRD Complex PML Body Centriolar Satellite	Nucleoplasm Cytoplasm Nuclear Body Protein-containing Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding DNA Helicase Activity RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding ATPase Activity Double-stranded DNA Helicase Activity Nucleosome-dependent ATPase Activity	DNA Binding RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Assembly Or Disassembly Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spindle Organization Centrosome Cycle DNA Duplex Unwinding ATP-dependent Chromatin Remodeling Regulation Of Signal Transduction By P53 Class Mediator	MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated Primary MiRNA Processing SnRNA Transcription By RNA Polymerase II Response To Arsenic-containing Substance Positive Regulation Of Neurogenesis Neuronal Stem Cell Population Maintenance
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS	RNA polymerase II transcribes snRNA genes mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Ischemic stroke ( 26089329) Macular thickness ( 30535121) Prostate cancer ( 29892016) Refractive error ( 32231278) Stroke ( 26089329)	Bipolar disorder ( 31043756) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Hemoglobin levels ( 32327693) Nonunion in individuals with fractures ( 30680360) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020) Resting heart rate ( 27798624) RR interval (heart rate) ( 30679814)
Interacting Genes		96 interacting genes: ACTR1B ADH5 AIMP2 ATP5IF1 BARD1 BCL6 BHLHE40 C4orf17 CASP6 CASP8 CPE CRCT1 CREB1 CREBBP CSTF2 CTBP1 CTTN ENTR1 FABP4 FBP2 FUBP1 GADD45A GIT1 GPS2 GSK3B H3C1 HABP4 HSD17B10 HSPH1 HTT IK IKZF1 IKZF3 IMMT IVNS1ABP KIF15 KPNA2 KPNB1 LRIF1 LUC7L2 MAFG MAN2A2 MX1 MYB NEFL NR1H2 NR4A1 PAICS PCMT1 PIAS4 PLK4 PRG2 PRPF40A PSME1 PTN PTPRS PUF60 RAD51 RETREG2 RGS2 RIF1 RPL29 SAFB SAT1 SATB1 SERBP1 SERF2 SGSM2 SIRT6 SKIL SLC27A6 SPOP SRRT SUMO1 SUMO2 TAL1 TCERG1 THOC7 TNFRSF14 TNNT1 TP53 TP73 TRIM28 TRIM54 TSC22D1 TSPAN6 TTR TXNDC9 UBA3 UBC UBE2I UROD VIM XRCC4 YAE1 ZHX1	14 interacting genes: APP CHD3 CSNK2A1 GEMIN4 GIT1 HNRNPK HSPA8 HTR6 IMMT SNRPF STAT3 SUMO2 VAV2 VIM
Entrez ID		1107	51593
HPRD ID		09071	10665
Ensembl ID		ENSG00000170004	ENSG00000087087
Uniprot IDs		B3KWV4 Q12873 Q2TAZ1	Q9BXP5
PDB IDs			5OO6 6F7J 6F7P 6F7S 6F8D
Enriched GO Terms of Interacting Partners?
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