NOXA1 and RAC2

Data Source:
HPRD (two hybrid)

		NOXA1	RAC2
Description		NADPH oxidase activator 1	Rac family small GTPase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol NADPH Oxidase Complex	Nuclear Envelope Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Enzyme Binding Small GTPase Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Superoxide Anion Generation Regulation Of Catalytic Activity Regulation Of Respiratory Burst	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Rac Protein Signal Transduction Cell Projection Assembly Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Regulation Of Mast Cell Degranulation Engulfment Of Apoptotic Cell Bone Resorption Cell Redox Homeostasis Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		RHO GTPases Activate NADPH Oxidases WNT5:FZD7-mediated leishmania damping	GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Rho GTPase cycle Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Dextromethorphan
Diseases			Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Response to fenofibrate (total cholesterol levels) ( 27002377)	Celiac disease ( 31591516) Graves' disease ( 23612905) Longevity ( 20834067) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)
Interacting Genes		57 interacting genes: ANKRD55 C19orf54 C9orf24 CACNA1A CEP70 CFP CRYBA1 CTDSP1 CYSRT1 DCLRE1B DDAH2 DUSP4 EP300 FAT1 GATAD2B IL16 KCTD15 KRTAP13-1 KRTAP15-1 KRTAP19-4 KRTAP19-7 KRTAP8-1 LASP1 LMO2 MAPK1 MAPK11 METTL27 MORN3 MYLIP NAA10 NADSYN1 NCF1 NDUFAB1 NOX1 NOXO1 PFDN5 PLA2G10 PRKACA PRKCA PRKCG QARS1 RAC1 RAC2 REL RIMBP3 RIMBP3C SMUG1 TCF19 TCF4 TGS1 TRAF2 TRIM23 UBAP2 WDR83 ZC2HC1C ZNF474 ZNF620	22 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB CDC42 CHGB CUL1 DEF6 DOCK2 GDI1 HDAC7 ICMT NCF2 NOS2 NOXA1 PAK2 RTKN SMAD1 SMAD4
Entrez ID		10811	5880
HPRD ID		17644	03628
Ensembl ID		ENSG00000188747	ENSG00000128340
Uniprot IDs		Q86UR1	A0A024R1P2 P15153 V9H0H7
PDB IDs			1DS6 2W2T 2W2V 2W2X
Enriched GO Terms of Interacting Partners?
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