NOXA1 and NCF1

Data Source:
BioGRID (two hybrid)

		NOXA1	NCF1
Description		NADPH oxidase activator 1	neutrophil cytosolic factor 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol NADPH Oxidase Complex	Cytoplasm Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body
	Molecular Function	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Enzyme Binding Small GTPase Binding	Protein Binding Electron Transfer Activity Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Molecular Adaptor Activity
	Biological Process	Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Superoxide Anion Generation Regulation Of Catalytic Activity Regulation Of Respiratory Burst	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Targeting To Membrane Superoxide Metabolic Process Apoptotic Process Cellular Defense Response Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Electron Transport Chain Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Superoxide Anion Generation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Cadmium Ion Positive Regulation Of P38MAPK Cascade
Pathways		RHO GTPases Activate NADPH Oxidases WNT5:FZD7-mediated leishmania damping	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases
Drugs			Dextromethorphan
Diseases			Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Response to fenofibrate (total cholesterol levels) ( 27002377)
Interacting Genes		57 interacting genes: ANKRD55 C19orf54 C9orf24 CACNA1A CEP70 CFP CRYBA1 CTDSP1 CYSRT1 DCLRE1B DDAH2 DUSP4 EP300 FAT1 GATAD2B IL16 KCTD15 KRTAP13-1 KRTAP15-1 KRTAP19-4 KRTAP19-7 KRTAP8-1 LASP1 LMO2 MAPK1 MAPK11 METTL27 MORN3 MYLIP NAA10 NADSYN1 NCF1 NDUFAB1 NOX1 NOXO1 PFDN5 PLA2G10 PRKACA PRKCA PRKCG QARS1 RAC1 RAC2 REL RIMBP3 RIMBP3C SMUG1 TCF19 TCF4 TGS1 TRAF2 TRIM23 UBAP2 WDR83 ZC2HC1C ZNF474 ZNF620	28 interacting genes: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF2 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN SH3RF1 SRSF2 SYTL1 TRAF4 TRIM9
Entrez ID		10811	653361
HPRD ID		17644
Ensembl ID		ENSG00000188747	ENSG00000158517
Uniprot IDs		Q86UR1	P14598
PDB IDs			1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP
Enriched GO Terms of Interacting Partners?
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