RAC2 and ADAM22

Data Source:
BioGRID (two hybrid)

		RAC2	ADAM22
Description		Rac family small GTPase 2	ADAM metallopeptidase domain 22
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GO Annotations	Cellular Component	Nuclear Envelope Cytosol Cytoskeleton Actin Filament Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium Phagocytic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome	Plasma Membrane Integral Component Of Membrane Axon Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Regulator Activity Protein Kinase Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Signal Transduction G Protein-coupled Receptor Signaling Pathway Motor Neuron Axon Guidance Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Rac Protein Signal Transduction Cell Projection Assembly Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of T Cell Proliferation Regulation Of Mast Cell Degranulation Engulfment Of Apoptotic Cell Bone Resorption Cell Redox Homeostasis Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Regulation Of Respiratory Burst Regulation Of Mast Cell Chemotaxis Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration Positive Regulation Of Protein Targeting To Mitochondrion	Proteolysis Cell Adhesion Negative Regulation Of Cell Adhesion Central Nervous System Development Adult Locomotory Behavior Myelination In Peripheral Nervous System Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
Pathways		GPVI-mediated activation cascade ROS and RNS production in phagocytes PIP3 activates AKT signaling Rho GTPase cycle Constitutive Signaling by Aberrant PI3K in Cancer PCP/CE pathway RHO GTPases Activate NADPH Oxidases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	LGI-ADAM interactions
Drugs		Dextromethorphan
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Celiac disease ( 31591516) Graves' disease ( 23612905) Longevity ( 20834067) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Type 1 diabetes ( 25751624)	Blood protein levels ( 30072576) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126)
Interacting Genes		22 interacting genes: ACTB ADAM22 AFG3L2 AGAP2 ARFIP2 ARHGDIA ARHGDIB CDC42 CHGB CUL1 DEF6 DOCK2 GDI1 HDAC7 ICMT NCF2 NOS2 NOXA1 PAK2 RTKN SMAD1 SMAD4	6 interacting genes: APP EPS8 LGI1 RAC2 YWHAB YWHAZ
Entrez ID		5880	53616
HPRD ID		03628	04751
Ensembl ID		ENSG00000128340	ENSG00000008277
Uniprot IDs		A0A024R1P2 P15153 V9H0H7	Q08AL8 Q9P0K1
PDB IDs		1DS6 2W2T 2W2V 2W2X	3G5C 5Y2Z 5Y31
Enriched GO Terms of Interacting Partners?
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