CFL1 and SSH1

Data Source:
HPRD (in vivo)

		CFL1	SSH1
Description		cofilin 1	slingshot protein phosphatase 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix Lamellipodium Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Lamellipodium Growth Cone Midbody Cleavage Furrow Synapse
	Molecular Function	Protein Binding Actin Filament Binding	Actin Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Cytoskeleton Organization Rho Protein Signal Transduction Response To Virus Viral Process Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Interleukin-12-mediated Signaling Pathway Positive Regulation Of Embryonic Development Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Process Cell Motility Actin Filament Severing Establishment Of Spindle Localization Regulation Of Dendritic Spine Morphogenesis	Cell Morphogenesis Protein Dephosphorylation Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Synaptic Plasticity Regulation Of Cellular Protein Metabolic Process Peptidyl-tyrosine Dephosphorylation Cellular Response To ATP Excitatory Chemical Synaptic Transmission Positive Regulation Of Neuron Death Positive Regulation Of AMPA Glutamate Receptor Clustering Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Dodecyldimethylamine N-oxide Copper Artenimol
Diseases
GWAS		Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Neutrophil count ( 32888494) Platelet count ( 32888494) Psoriasis ( 28537254) White blood cell count ( 32888494)	Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 27863252) Platelet count ( 32888494)
Interacting Genes		43 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR ERBB2 ERBB3 ERBB4 ESR1 HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UCHL5 WDR1 YWHAG YWHAQ YWHAZ	6 interacting genes: ACTB AKT1 CFL1 CFL2 CORO1B DSTN
Entrez ID		1072	54434
HPRD ID		03261	09486
Ensembl ID		ENSG00000172757	ENSG00000084112
Uniprot IDs		P23528 V9HWI5	Q8WYL5
PDB IDs		1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W 6UBY 6UC0 6UC4 6VAO
Enriched GO Terms of Interacting Partners?
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