SSH1 and DSTN

Data Source:
BioGRID (enzymatic study)

		SSH1	DSTN
Description		slingshot protein phosphatase 1	destrin, actin depolymerizing factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Lamellipodium Growth Cone Midbody Cleavage Furrow Synapse	Cytoplasm Actin Cytoskeleton Cortical Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Actin Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Protein Binding Actin Filament Binding
	Biological Process	Cell Morphogenesis Protein Dephosphorylation Actin Cytoskeleton Organization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Synaptic Plasticity Regulation Of Cellular Protein Metabolic Process Peptidyl-tyrosine Dephosphorylation Cellular Response To ATP Excitatory Chemical Synaptic Transmission Positive Regulation Of Neuron Death Positive Regulation Of AMPA Glutamate Receptor Clustering Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Excitatory Postsynaptic Potential	Actin Polymerization Or Depolymerization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Cell Motility Actin Filament Severing
Pathways
Drugs			Dodecyldimethylamine N-oxide
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Mean platelet volume ( 27863252) Platelet count ( 32888494)	Coronary artery disease ( 29212778) Presence of antiphospholipid antibodies ( 23509613)
Interacting Genes		6 interacting genes: ACTB AKT1 CFL1 CFL2 CORO1B DSTN	8 interacting genes: ACTB ACTG1 CFL2 SHBG SMAD9 SSH1 TAX1BP1 TESK2
Entrez ID		54434	11034
HPRD ID		09486	16446
Ensembl ID		ENSG00000084112	ENSG00000125868
Uniprot IDs		Q8WYL5	P60981 V9HWA6
PDB IDs
Enriched GO Terms of Interacting Partners?
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